Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis

Authors

  • Ahmed M. Elsharkawy,

    1. Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
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  • Derek A. Mann

    Corresponding author
    1. Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    • Liver Group, Institute of Cellular Medicine, 4th Floor, Cookson Building, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
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    • fax: (44) 191 2225455.


  • Potential conflict of interest: Nothing to report.

Abstract

Nuclear factor-κB (NF-κB) is a transcriptional regulator of genes involved in immunity, inflammatory response, cell fate, and function. Recent attention has focused on the pathophysiological role of NF-κB in the diseased liver. In vivo studies using rodent models of liver disease and cell-targeted perturbation of NF-κB activity have revealed complex and multicellular functions in hepatic inflammation, fibrosis, and the development of hepatocellular carcinoma—a process we have termed the “inflammation-fibrosis-cancer axis”. This review summarizes the current state of knowledge and provides insight into the vast complexity of the hepatic NF-κB signaling system, which should provide a rich source of new therapeutic targets. (HEPATOLOGY 2007;46:590–597.)

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