These authors contributed equally to this study.
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice†
Version of Record online: 17 AUG 2007
Copyright © 2007 American Association for the Study of Liver Diseases
Volume 46, Issue 5, pages 1564–1573, November 2007
How to Cite
Sakamori, R., Takehara, T., Ohnishi, C., Tatsumi, T., Ohkawa, K., Takeda, K., Akira, S. and Hayashi, N. (2007), Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. Hepatology, 46: 1564–1573. doi: 10.1002/hep.21837
Potential conflict of interest: Nothing to report.
- Issue online: 29 OCT 2007
- Version of Record online: 17 AUG 2007
- Manuscript Accepted: 25 MAY 2007
- Manuscript Received: 13 MAR 2007
- Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
Supplementary material for this article can be found on the H EPATOLOGY website ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).
|jws-hep.21837.fig1.pdf||51K||Supplementary Fig. 1 Plasma insulin levels before and after CLP. L-STAT3 KO mice (KO) or wild-type littermates (WT) were treated with CLP (n = 8 in each group). Before and 24 hours after CLP, blood samples were obtained from mice and subjected to the analysis of insulin. * P < 0.05.|
|jws-hep.21837.fig2.pdf||46K||Supplementary Fig. 2 TNFá production in LPS-stimulated RAW cells in the presence of haptoglobin. RAW cells were cultured for 24 hours with RPMI supplemented with the indicated amount of haptoglobin in the presence of LPS. TNFá production was determined by ELISA.|
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