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Supplementary material for this article can be found on the H EPATOLOGY Web site ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).

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jws-hep.21872.fig1.pdf119K Supplementary Fig. 1. Cytokine production of intrahepatic NKT cells in HBs-Tg mice after a low dose of Con A injection.After 1 h stimulation of Con A (3 μg/g body weight) or PBS, intrahepatic NKT cells were analyzed by flow cytometry for the production of IFN-γ and IL-4. These were from a single experiment representative of three independent experiments. PBS, phosphatebuffered saline; Con A, concanavalin A; IFN-γ, interferon-gamma; IL-4, interleukin-4.
jws-hep.21872.fig2.pdf98K Supplementary Fig. 2. Neutralization of IFN-g or IL-4 alleviated over-sensitive liver injury in HBs-Tg mice after a low dose of Con A injection.IFN-γ(A) or IL-4 (B) was neutralized by the indicated antibody in HBs-Tg mice before Con A (3 μg/g body weight) injection respectively. Serum ALT and AST were determined 18 h after Con A injection. Data were shown as mean ± SEM from four mice in each group. Con A, concanavalin A; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Ig, immunoglobulin; Ab, antibody; IFN-γ, interferon-gamma; IL-4, interleukin-4.
jws-hep.21872.fig3.pdf115K Supplementary Fig. 3. Neutralization of IFN-g or IL-4 inhibited NK cell activation in HBs-Tg mice after a low dose of Con A injection.IFN-γ or IL-4 was neutralized by the indicated antibody in HBs-Tg mice before Con A (3 μg/g body weight) injection respectively. At 18 h of Con A injection, CD69 expression on intrahepatic NK cells was analyzed by flow cytometry. The gray histogram was for the NK cells from control HBs-Tg mice with PBS injection. Ig, immunoglobulin; Ab, antibody; IFN-γ, interferon-gamma; IL-4, interleukin-4.

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