These authors contributed equally to this work.
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Hepatobiliary Malignancies
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Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma†
Article first published online: 10 SEP 2007
DOI: 10.1002/hep.21893
Copyright © 2007 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Xu, R., Zhang, X., Zhang, W., Fang, Y., Zheng, S. and Yu, X.-F. (2007), Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma. Hepatology, 46: 1810–1820. doi: 10.1002/hep.21893
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Potential conflict of interest: Nothing to report.
- ‡
These authors contributed equally to this work.
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Publication History
- Issue published online: 28 NOV 2007
- Article first published online: 10 SEP 2007
- Manuscript Accepted: 25 JUN 2007
- Manuscript Received: 22 JAN 2007
Funded by
- National Science Foundation of China. Grant Number: NSFC-30425012
- Cheung Kong Scholars Program Foundation of the Chinese Ministry of Education
- Research grants from the NIH. Grant Number: AI062644
References
- 1, . Hepatitis B virus and hepatocellular carcinoma. Int J Exp Pathol 2001; 82: 77–100.
- 2, , , . Molecular viral oncology of hepatocellular carcinoma. Oncogene 2003; 22: 5093–5107.
- 3
- 4, , , , , , et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295: 65–73.
- 5, . The enigmatic X gene of hepatitis B virus. J Virol 2004; 78: 12725–12734.
- 6, . Knock-down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells. J Pathol 2006; 208: 372–380.
- 7, , , . Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. Cancer Res 2003; 63: 3453–3458.
- 8, . Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene. Nucl Acids Res 2004; 32: 2202–2213.
- 9, , , , , , et al. Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2. HEPATOLOGY 2003; 38: 1258–1266.
- 10, , , , , , et al. Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res 2001; 61: 7803–7810.
- 11, , , , , . Characterization of HBV integrants in 14 hepatocellular carcinomas:association of truncated X gene and hepatocellular carcinogenesis. Oncogene 2004; 23: 142–148.
- 12, . Human hepatitis B virus X protein induces apoptosis in HepG2 cells: role of BH3 domain. Biochem Biophys Res Commun 2005; 338: 1551–1556.
- 13, , , , , , et al. Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism. Cell Mol Immunol 2005; 2: 40–48.
- 14, , , , , , et al. Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection. J Hepatol 2003; 39: 253–261.
- 15, , , . Dominant mutations of hepatitis B virus mutants in hepatoma accumulate in B-cell and T-cell epitopes of the HBx antigen. Virus Res 2003; 92: 157–164.
- 16, , , , , , et al. Different expression of hepatitis B surface antigen between hepatocellular carcinoma and its surrounding liver tissue, studied using a tissue microarray. J Pathol 2002; 197: 610–616.
- 17, , , , , . Identification of hepatitis B virus X gene mutation in Hong Kong patients with hepatocellular carcinoma. J Clin Virol 2005; 34: 7–12.
- 18, , , , , . Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo. Proc Natl Acad Sci U S A 2005; 102: 8321–8326.
- 19, , , , , , et al. G to A hypermutation of hepatitis B virus. HEPATOLOGY 2005; 41: 626–633.
- 20, , , . Inhibition of hepatitis B virus replication by APOBEC3G. Science 2004; 303: 1829.
- 21, , , , . Comment on “Inhibition of hepatitis B virus replication by APOBEC3G”. Science 2004; 305: 1403a.
- 22, , , , , , et al. Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication. HEPATOLOGY 2006; 43: 1364–1374.
- 23, , , , , , et al. Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes. Biochem Biophys Res Commun 2006; 341: 314–319.
- 24, , , , , , et al. Naturally occurring hepatitis B virus genomes bearing the hallmarks of retroviral G–>A hypermutation. Virology 1997; 235: 104–108.
- 25, , , , . Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR. J Gen Virol 2005; 86: 125–129.
- 26, , , , , , et al. Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science 2003; 302: 1056–1060.
- 27, , , . Residual subset population analysis in WBC-reduced blood components using real-time PCR quantitation of specific mRNA. Transfusion 2001; 41: 1591–1600.
- 28, , , , . Induction of HSF1 expression is associated with sporadic colorectal cancer. World J Gastroenterol 2004; 10: 3122–3126.
- 29, , , , , . Cytidine deamination of retroviral DNA by diverse APOBEC proteins. Curr Biol 2004; 14: 1392–1396.
- 30, , . Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif. Virology 2005; 339: 281–288.
- 31, , , . Heat shock-independent induction of multidrug resistance by heat shock factor 1. Mol Cell Biol 2006; 26: 580–591.
- 32, , , , , , et al. A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma. Am J Pathol 2000; 156: 857–864.
- 33, , . APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast. Proc Natl Acad Sci U S A 2005; 102: 9854–9859.
- 34, . Hydrolytic nucleoside and nucleotide deamination, and genetic instability: a possible link between RNA-editing enzymes and cancer? Trends Mol Med 2003; 9: 147–152.
- 35, , , , , , et al. Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. Proc Natl Acad Sci U S A 2006; 103: 8780–8785.
- 36, , , , , , et al. APOBEC3 proteins inhibit human LINE-1 retrotransposition. J Biol Chem 2006; 281: 22161–22172.