Article first published online: 19 DEC 2007
Copyright © 2008 American Association for the Study of Liver Diseases
Volume 47, Issue 4, pages 1128–1135, April 2008
How to Cite
Wise, M., Bialek, S., Finelli, L., Bell, B. P. and Sorvillo, F. (2008), Changing trends in hepatitis C–related mortality in the United States, 1995-2004. Hepatology, 47: 1128–1135. doi: 10.1002/hep.22165
The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the funding agencies.
Potential conflict of interest: Nothing to report.
- Issue published online: 25 MAR 2008
- Article first published online: 19 DEC 2007
- Accepted manuscript online: 19 DEC 2007 12:00AM EST
- Manuscript Accepted: 28 NOV 2007
- Manuscript Received: 14 JUN 2007
- NIH/NIAID T32AI07481: Interdisciplinary Training Program in HIV/AIDS Epidemiology
The disease burden and mortality from hepatitis C are predicted to increase in the United States as the number of persons with long-standing chronic infection grows. We analyzed hepatitis C mortality rates derived from US Census and multiple-cause-of-death data for 1995-2004. Deaths were considered hepatitis C–related if: (1) hepatitis C was the underlying cause of death, (2) chronic liver disease was the underlying cause and hepatitis C was a contributing cause, or (3) human immunodeficiency virus was the underlying cause and chronic liver disease and hepatitis C were contributing causes. A total of 56,409 hepatitis C–related deaths were identified. Mortality rates increased 123% during the study period (1.09 per 100,000 persons to 2.44 per 100,000), but average annual increases were smaller during 2000-2004 than 1995-1999. After peaking in 2002 (2.57 per 100,000), overall rates declined slightly, but continued to increase among persons aged 55-64 years. Overall increases were greater among males (144%) than females (81%) and among non-Hispanic blacks (170%) and Native Americans (241%) compared to non-Hispanic whites (124%) and Hispanics (84%). The 7,427 hepatitis C deaths in 2004 (mean age: 55 years), corresponded to 148,611 years of potential life lost. The highest mortality rates in 2004 were observed among males, persons aged 45-54 and 55-64 years, Hispanics, non-Hispanic blacks, and non-Hispanic Native American/Alaska Natives. Conclusion: Overall, hepatitis C mortality has increased substantially since 1995. Despite small declines in recent years, rates have continued to increase among persons aged 55-64 years. Hepatitis C is an important cause of premature mortality. (HEPATOLOGY 2008.)