Coordinate regulation of gallbladder motor function in the gut-liver axis

Authors

  • Piero Portincasa,

    Corresponding author
    1. Department of Internal Medicine and Public Medicine, Clinica Medica “A. Murri”, University of Bari Medical School, Bari, Italy
    • Section of Internal Medicine, Department of Internal and Public Medicine, University Medical School, Piazza Giulio Cesare 11, Policlinico, 70124 Bari, Italy
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    • fax +39 80-5478232

  • Agostino Di Ciaula,

    1. Department of Internal Medicine and Public Medicine, Clinica Medica “A. Murri”, University of Bari Medical School, Bari, Italy
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  • Helen H. Wang,

    1. Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA
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  • Giuseppe Palasciano,

    1. Department of Internal Medicine and Public Medicine, Clinica Medica “A. Murri”, University of Bari Medical School, Bari, Italy
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  • Karel J. van Erpecum,

    1. Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
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  • Antonio Moschetta,

    1. Department of Internal Medicine and Public Medicine, Clinica Medica “A. Murri”, University of Bari Medical School, Bari, Italy
    2. Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro (CH), Italy
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  • David Q.-H. Wang

    1. Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA
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  • Potential conflict of interest: Nothing to report.

Abstract

Gallstones are one of the most common digestive diseases with an estimated prevalence of 10%-15% in adults living in the western world, where cholesterol-enriched gallstones represent 75%-80% of all gallstones. In cholesterol gallstone disease, the gallbladder becomes the target organ of a complex metabolic disease. Indeed, a fine coordinated hepatobiliary and gastrointestinal function, including gallbladder motility in the fasting and postprandial state, is of crucial importance to prevent crystallization and precipitation of excess cholesterol in gallbladder bile. Also, gallbladder itself plays a physiopathological role in biliary lipid absorption. Here, we present a comprehensive view on the regulation of gallbladder motor function by focusing on recent discoveries in animal and human studies, and we discuss the role of the gallbladder in the pathogenesis of gallstone formation. (HEPATOLOGY 2008;47:2112–2126.)

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