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Viral Hepatitis
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Ribavirin exposure after the first dose is predictive of sustained virological response in chronic hepatitis C†
Article first published online: 14 JAN 2008
DOI: 10.1002/hep.22217
Copyright © 2008 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Loustaud-Ratti, V., Alain, S., Rousseau, A., Hubert, I. F., Sauvage, F. L., Marquet, P., Denis, F., Lunel, F., Calès, P., Lefebvre, A., Fauchais, A.-L., Liozon, E. and Vidal, E. (2008), Ribavirin exposure after the first dose is predictive of sustained virological response in chronic hepatitis C. Hepatology, 47: 1453–1461. doi: 10.1002/hep.22217
- †
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 24 APR 2008
- Article first published online: 14 JAN 2008
- Accepted manuscript online: 14 JAN 2008 12:00AM EST
- Manuscript Accepted: 20 DEC 2007
- Manuscript Received: 11 JUL 2007
Funded by
- Centre Hospitalier Universitaire de Limoges
- Roche, France
References
- 1, , , , , , et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958–965.
- 2, , , , , , et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975–982.
- 3. The clinical pharmacology of ribavirin. Semin Liver Dis 1999; 19: 17–24.
- 4, , , , . Population pharmacokinetic and pharmacodynamic analysis of ribavirin in patients with chronic hepatitis C. Ther Drug Monit 2000; 22: 555–565.
- 5, , , , , , et al. Ribavirin dosing in chronic hepatitis C: application of population pharmacokinetic-pharmacodynamic models. Clin Pharmacol Ther 2002; 72: 349–361.
- 6, , , , , . Ribavirin quantification in combination treatment of chronic hepatitis C. Antimicrob Agents Chemother. 2003; 47: 124–129.
- 7, , , . Dosage of ribavirin in patients with hepatitis C should be based on renal function: a population pharmacokinetic analysis. Ther Drug Monit 2002; 24: 701–708.
- 8, , , . High-dose ribavirin in combination with standard dose peginterferon for treatment of patients with chronic hepatitis C. HEPATOLOGY 2005; 41: 275–279.Direct Link:
- 9, , , , , , et al. Triple therapy with amantadine in treatment-naive patients with chronic hepatitis C: a placebo-controlled trial. HEPATOLOGY 2003; 37: 1359–1367.Direct Link:
- 10, , , , , , et al.; the International Hepatitis Interventional Therapy Group. Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C. Gastroenterology 2002; 123: 1061–1069.
- 11, . The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cell Mol Life Sci 2006; 63: 832–842.
- 12, , , , , , et al. Ribavirin disposition in high-risk patients for acquired immunodeficiency syndrome. Clin Pharmacol Ther 1987; 41: 546–555.
- 13, , , , . Pharmacokinetics of ribavirin in patients with hepatitis C virus. Br J Clin Pharmacol 2006; 62: 710–714.Direct Link:
- 14, , , , , . The single dose pharmacokinetics of ribavirin in subjects with chronic liver disease. Br J Clin Pharmacol 2000; 49: 417–421.Direct Link:
- 15, , , , , , et al. Early ribavirin pharmacokinetics, HCV RNA and alanine aminotransferase kinetics in HIV/HCV co-infected patients during treatment with pegylated interferon and ribavirin. J Hepatol 2007; 47: 23–30.
- 16, , , , , , et al. Ribavirin and interferon alfa-2b in chronic hepatitis C: assessment of possible pharmacokinetic and pharmacodynamic interactions. Br J Clin Pharmacol 1998; 46: 563–570.Direct Link:
- 17, , , , , , et al. Antiviral action of ribavirin in chronic hepatitis C. Gastroenterology 2004; 126: 703–714.
- 18, . Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature 2005; 436: 967–972.
- 19, , , . Modelling how ribavirin improves interferon response rates in hepatitis C virus infection. Nature 2004; 432: 922–924.
- 20, , , , The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA. Virology 2003; 310: 333–342.
- 21, , , , , , et al. Mutagenic effects of ribavirin and response to interferon/ribavirin combination therapy in chronic hepatitis C. J Hepatol 2005; 43: 623–629.
- 22, , , , . Analysis of ribavirin mutagenicity in human hepatitis C virus infection. J Virol 2007; 81: 7732–7741.
- 23, , , , , , et al. Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response. HEPATOLOGY 2007; 46: 1548–1563.Direct Link:
- 24, , , , , , et al. Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells. J Virol 2003; 77: 5933–5947.
- 25, , , , , , et al. Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer. J Clin Oncol 1998; 16: 187–196.

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