These authors contributed equally to this study.
Steatohepatitis/Metabolic Liver Disease
Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor†
Article first published online: 1 FEB 2008
Copyright © 2008 American Association for the Study of Liver Diseases
Volume 47, Issue 6, pages 1924–1935, June 2008
How to Cite
Lin, H.-Y., Yu, I.-C., Wang, R.-S., Chen, Y.-T., Liu, N.-C., Altuwaijri, S., Hsu, C.-L., Ma, W.-L., Jokinen, J., Sparks, J. D., Yeh, S. and Chang, C. (2008), Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor. Hepatology, 47: 1924–1935. doi: 10.1002/hep.22252
Potential conflict of interest: Nothing to report.
- Issue published online: 28 MAY 2008
- Article first published online: 1 FEB 2008
- Accepted manuscript online: 1 FEB 2008 12:00AM EST
- Manuscript Accepted: 22 JAN 2008
- Manuscript Received: 13 SEP 2007
- National Institutes of Health. Grant Number: DK073414
- George Whipple Professor Endowment
Supplementary material for this article can be found on the H EPATOLOGY Web site ( http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html ).
|hep22252-SupplementaryFigure1.tif||8229K||Supplementary Fig. 1. Growth curve, cumulative weight gain, and liver weight of female AR +/+ , H-AR /+ and H-AR / mice on HFD. Mice were fed HFD for 8 weeks starting when they were 8 weeks old. (A) Growth curves of animals fed normal chow. (B) Growth curves of animals fed HFD. (C) There were no significant genotype-dependent differences in liver weight between female mice fed normal chow and those fed an HFD.|
|hep22252-SupplementaryFigure2.tif||8228K||Supplementary Fig. 2. Fasted glucose level in female AR +/+ , H-AR /+ , and H-AR / mice on an HFD. There were no significant genotype-dependent differences in fasted glucose level in female mice fed normal chow or a HFD.|
|hep22252-SupplementaryFigure3.tif||8228K||Supplementary Fig. 3. Expression of Ptp1b and genes involved in lipogenesis determined by QPCR. Hepatic expression of lipogenic genes showed no significant genotype differences in female AR +/+ , H-AR /+ , and H-AR / mice on HFD, but expression of PTP1B was lower in H-AR / mice fed HFD. Data are means ± SEMs of 3 independent experiments (*P < 0.05 AR +/+ (HFD) versus H-AR / (HFD).|
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