fax: +46-31-41 12 56
Viral Hepatitis
You have full text access to this OnlineOpen article
Randomized comparison of 12 or 24 weeks of peginterferon α-2a and ribavirin in chronic hepatitis C virus genotype 2/3 infection†
Article first published online: 1 FEB 2008
DOI: 10.1002/hep.22253
Copyright © 2008 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Lagging, M., Langeland, N., Pedersen, C., Färkkilä, M., Buhl, M. R., Mørch, K., Dhillon, A. P., Alsiö, Å., Hellstrand, K., Westin, J. and Norkrans, G. (2008), Randomized comparison of 12 or 24 weeks of peginterferon α-2a and ribavirin in chronic hepatitis C virus genotype 2/3 infection. Hepatology, 47: 1837–1845. doi: 10.1002/hep.22253
- †
Potential conflict of interest: Dr. Lagging is a consultant for Schering-Plough, Roche, and Abbott.
Publication History
- Issue published online: 28 MAY 2008
- Article first published online: 1 FEB 2008
- Accepted manuscript online: 1 FEB 2008 12:00AM EST
- Manuscript Accepted: 23 JAN 2008
- Manuscript Received: 27 AUG 2007
Funded by
- Swedish Society of Medicine
- Swedish Medical Research Council
- Swedish Society of Microbiology
- Avtal om läkarutbildning och forskning (ALF) Funds. Grant Number: ALFGBG-3149
- Roche affiliates in the Nordic region
- Abstract
- Article
- References
- Cited By
Cited in:
- CrossRef
This article has been cited by:
- 1, , , , , , , , , , , , , , , APASL consensus statements and management algorithms for hepatitis C virus infection, Hepatology International, 2012, 6, 2, 409
- 2, , , , , , , , Response-guided therapy based on reaction to the initial dose using administration of peginterferon α-2a alone or in combination with ribavirin in naïve patients with chronic hepatitis C of serotype 2 and high viral loads, Kanzo, 2012, 53, 1, 18
- 3, , , Response-guided and -unguided treatment of chronic hepatitis C, Liver International, 2012, 32,Direct Link:
- 4, , , , , , , , , , Response-guided therapy for patients with chronic hepatitis who have high viral loads of hepatitis C virus genotype 2, Hepatology Research, 2012, 42, 6Direct Link:
- 5, , , , , Steatosis is the predictor of relapse in HCV genotype 3- but not 2-infected patients treated with 12 weeks of pegylated interferon-α-2a plus ribavirin and RVR, Journal of Viral Hepatitis, 2012, 19, 5Direct Link:
- 6, , , âEasy to treatâ genotypes were not created equal: Can rapid virological response (RVR) level the playing field?, Journal of Hepatology, 2011, 55, 2, 466
- 7, , Chronic hepatitis C genotype 2 and 3: Are we ready for personalized medicine?, Journal of Hepatology, 2011, 55, 3, 505
- 8, Consensus Interferon: Tailored Therapy and the Impact of Adherence, Digestive Diseases and Sciences, 2011, 56, 3, 631
- 9, Current Therapies for Chronic Hepatitis C, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2011, 31, 1Direct Link:
- 10, , , , , , , , , , , Early quantification of HCV core antigen may help to determine the duration of therapy for chronic genotype 2 or 3 HCV infection, European Journal of Clinical Microbiology & Infectious Diseases, 2011,
- 11, , , , , , , , , Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon alfa-2a and ribavirin, Journal of Hepatology, 2011, 54, 5, 866
- 12, , , , , , , , , , Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: A Danish nationwide cohort study, BMC Infectious Diseases, 2011, 11, 1, 177
- 13
- 14, , , , , , , , , , , , , Hepatic steatosis in chronic hepatitis C patients infected with genotype 2 is associated with insulin resistance, hepatic fibrosis and affects cumulative positivity of serum hepatitis C virus RNA in peginterferon and ribavirin combination therapy, Hepatology Research, 2011, 41, 12Direct Link:
- 15, , , , , , , , , , , , , , , Hepatitis C treatment response kinetics and impact of baseline predictors, Journal of Viral Hepatitis, 2011, 18, 6Direct Link:
- 16, , , , , , , , , , , , Hepatitt C - utredning og behandling, Tidsskrift for Den norske legeforening, 2011, 131, 1, 2
- You have free access to this content17, Individualizing treatment duration in hepatitis C virus genotype 2/3-infected patients, Liver International, 2011, 31, 1Direct Link:
- 18, , , , , , , , , , , Interleukin 28B Gene Variation at rs12979860 Determines Early Viral Kinetics During Treatment in Patients Carrying Genotypes 2 or 3 of Hepatitis C Virus, Journal of Infectious Diseases, 2011, 203, 12, 1748
- 19, , , , Is HCV RNA analysis at day 7 cost-effective in deciding the duration of therapy in chronic HCV genotype 2/3 infection?, Journal of Hepatology, 2011, 54, 4, 835
- You have free access to this content20, , Optimal therapy in hepatitis C virus genotypes 2 and 3 patients, Liver International, 2011, 31,Direct Link:
- 21, , , , , , , , , , Pegylated interferon-alfa-2a monotherapy in patients infected with HCV genotype 2 and importance of rapid virological response, BMC Research Notes, 2011, 4, 1, 316
- 22, , , , , , , , Prediction of Sustained Virological Response to Combination Therapy with Pegylated Interferon Alfa and Ribavirin in Patients with Genotype 3 Chronic Hepatitis C, Digestive Diseases and Sciences, 2011, 56, 8, 2449
- 23, , , , , , , , , , , , , , , , , , , , Reduced dose and duration of peginterferon alfa-2b and weight-based ribavirin in patients with genotype 2 and 3 chronic hepatitis C, Journal of Hepatology, 2011, 55, 3, 554
- 24, , , , , , , , , , , , , , , , , , , Response to Peginterferon-alfa 2b and Ribavirin in Japanese Patients with Chronic Hepatitis C Genotype 2, Digestive Diseases and Sciences, 2011, 56, 11, 3335
- 25, , , , , , , , , , Response-guided peg-interferon plus ribavirin treatment duration in chronic hepatitis C: Meta-analyses of randomized, controlled trials and implications for the future, Hepatology, 2011, 54, 3Direct Link:
- 26, , , , , , , , , , , Ribavirin plasma concentration is a predictor of sustained virological response in patients treated for chronic hepatitis C virus genotype 2/3 infection, Journal of Viral Hepatitis, 2011, 18, 4Direct Link:
- 27, , , , , , , , , , , , , Steatosis Is an Independent Predictor of Relapse Following Rapid Virologic Response in Patients With HCV Genotype 3, Clinical Gastroenterology and Hepatology, 2011, 9, 8, 688
- 28, , , , , , , , Ultra-Rapid Virological Response, Young Age, Low γ-GT/ALT-Ratio, and Absence of Steatosis Identify a Subgroup of HCV Genotype 3 Patients Who Achieve SVR with IFN-α2a Monotherapy, Digestive Diseases and Sciences, 2011, 56, 11, 3296
- 29, , , , , , , , , , , Evaluation of depression as a risk factor for treatment failure in chronic hepatitis C, Hepatology, 2010, 52, 2Direct Link:
- 30, , , , , , , , , , , , , , , , , , , , , , , , Factors affecting efficacy in patients with genotype 2 chronic hepatitis C treated by pegylated interferon alpha-2b and ribavirin: reducing drug doses has no impact on rapid and sustained virological responses, Journal of Viral Hepatitis, 2010, 17, 5Direct Link:
- 31, HCV Response-Guided Therapy: Should Treatment Length Be Shortened or Extended?, Current Hepatitis Reports, 2010, 10, 1, 4
- 32, , , , , , , , Identifying hepatitis C virus genotype 2/3 patients who can receive a 16-week abbreviated course of peginterferon alfa-2a (40KD) plus ribavirin, Hepatology, 2010, 51, 6Direct Link:
- 33, , , , In patients with HCV genotype 2 or 3 infection and RVR 14 weeks treatment is noninferior to 24 weeks. Pooled analysis of two Scandinavian trials, European Journal of Gastroenterology & Hepatology, 2010, 22, 5, 552
- 34, , , Increased Risk of Esophageal Varices, Liver Cancer, and Death in Patients With Alcoholic Liver Disease, Alcoholism: Clinical and Experimental Research, 2010, 34, 11Direct Link:
- 35, , , , , , , , , , , Management of hepatitis C; Report of the Consensus Meeting at the 45th Annual Meeting of the Japan Society of Hepatology (2009), Hepatology Research, 2010, 40, 4Direct Link:
- 36, More sensitive hepatitis C virus RNA detection: What for?, Journal of Hepatology, 2010, 52, 6, 783
- 37, , , , , Pegylated interferon plus optimized weight-based ribavirin dosing negate the influence of weight and body mass index on early viral kinetics and sustained virological response in chronic hepatitis C, Journal of Viral Hepatitis, 2010, 17, 12Direct Link:
- 38, , Pegylated-interferon plus ribavirin therapy in the treatment of CHC: individualization of treatment duration according to on-treatment virologic response, Current Medical Research and Opinion, 2010, 26, 7, 1733
- 39, Review article: the role of rapid virological response in determining treatment duration for chronic hepatitis C, Alimentary Pharmacology & Therapeutics, 2010, 31, 12Direct Link:
- 40, , , , , , , , , , , , Ribavirin dosage in patients with HCV genotypes 2 and 3 who completed short therapy with peg-interferon α-2b and ribavirin, Alimentary Pharmacology & Therapeutics, 2010, 31, 12Direct Link:
- 41, , , , , , , , , , , , , , Systemic and intrahepatic interferon-gamma-inducible protein 10 kDa predicts the first-phase decline in hepatitis C virus RNA and overall viral response to therapy in chronic hepatitis C, Hepatology, 2010, 51, 5Direct Link:
- 42, , Tailoring Treatment Duration to 12 to 16 Weeks in Hepatitis C Genotype 2 or 3 With Rapid Virologic Response, Journal of Clinical Gastroenterology, 2010, 1
- 43, Treatment Duration for Genotypes 2 and 3, Journal of Clinical Gastroenterology, 2010, 44, 8, 527
- 44, , , , , A crossing in therapy for hepatitis C virus genotype 2 or 3: Increasing ribavirin dose with shortened duration or reducing ribavirin dose with standard duration, Hepatology, 2009, 49, 4Direct Link:
- 45, , , , , , , , , , , , , , , , , , A randomized trial of 24 versus 48 weeks of peginterferon α-2a in patients infected with chronic hepatitis C virus genotype 2 or low viral load genotype 1: a multicenter national study in Japan, Hepatology International, 2009, 3, 3, 468
- 46, , , , Ãradication du virus de lâhépatite C après un traitement de cinq semaines, La Revue de Médecine Interne, 2009, 30, 10, 900
- 47
- 48, , , , , , , , , , , Hepatitis C Virus: A Critical Appraisal of Approaches to Therapy, Clinical Gastroenterology and Hepatology, 2009, 7, 4, 397
- 49, , , , Impact of early viral kinetics on pegylated interferon alpha 2b plus ribavirin therapy in Japanese patients with genotype 2 chronic hepatitis C, Journal of Viral Hepatitis, 2009, 16, 5Direct Link:
- 50, , , , , , , , , , , JSH Consensus Kobe 2009: Diagnosis and Treatment of Hepatitis C, Kanzo, 2009, 50, 11, 665
- 51, , , , Optimizing the Dose and Duration of Therapy for Chronic Hepatitis C, Gut and Liver, 2009, 3, 1, 1
- 52, , , , , Optimizing the treatment of chronic viral hepatitis C, Expert Review of Gastroenterology & Hepatology, 2009, 3, 6, 607
- 53, , Spotlight on Peginterferon-α-2a (40âkD) Plus Ribavirin in the Management of Chronic Hepatitis C Mono-Infectionâ , BioDrugs, 2009, 23, 1, 63
- 54, , Treatment of chronic hepatitis C in Asia: When East meets West, Journal of Gastroenterology and Hepatology, 2009, 24, 3Direct Link:
- 55, , Treatment of patients infected with chronic hepatitis C genotype 2 and 3: More data, more questions?, Hepatology, 2009, 49, 2Direct Link:
- 56
- 57, , When less may not be best—The challenge of individualising antiviral therapy for chronic hepatitis C infection, Journal of Gastroenterology and Hepatology, 2009, 24, 3Direct Link:
- 58, Peginterferon and ribavirin in HCV: Improvement of sustained viral response, Best Practice & Research Clinical Gastroenterology, 2008, 22, 6, 1109
- 59, , Short treatment to patients with genotype 2 or 3, Hepatology, 2008, 48, 2Direct Link:
- 60, , , , , , , , , , , , , Weight-adjusted dosing of ribavirin and importance of hepatitis C virus RNA below 1000 IU/mL by day 7 in short-term peginterferon therapy for chronic genotype 2/3 hepatitis C virus infection, Hepatology, 2008, 48, 2Direct Link:
- 61, , , Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3,Direct Link:
- 62, , , Genotypes 2 and 3 Relapse and Non-Response,Direct Link:
- 63, , Measuring Antiviral Responses,Direct Link:
- 64, , Standard Therapy for Genotypes 2/3,Direct Link:

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
