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Steatohepatitis/Metabolic Liver Disease
Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease†
Article first published online: 21 FEB 2008
DOI: 10.1002/hep.22292
Copyright © 2008 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Dunn, W., Xu, R. and Schwimmer, J. B. (2008), Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease. Hepatology, 47: 1947–1954. doi: 10.1002/hep.22292
- †
Potential conflict of interest: The funders did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. The authors have no financial conflicts of interest.
Publication History
- Issue published online: 28 MAY 2008
- Article first published online: 21 FEB 2008
- Accepted manuscript online: 21 FEB 2008 12:00AM EST
- Manuscript Accepted: 12 FEB 2008
- Manuscript Received: 7 NOV 2007
Funded by
- National Institutes of Health (NIH)
- National Research Service Award (NRSA). Grant Number: T32 DK07202
- NIH National Center for Research Resources for the General Clinical Research Center at the University of California, San Diego (UCSD). Grant Number: M01 RR000827
References
- 1, , , . Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits. BMJ 1996; 312: 731–736.
- 2, , , . AHA science advisory: wine and your heart: a science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the American Heart Association. Circulation 2001; 103: 472–475.
- 3, , , , . Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States. HEPATOLOGY 2006; 43: 1145–1151.Direct Link:
- 4, . Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003; 124: 71–79.
- 5, , , , , , et al. Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med 1997; 337: 1705–1714.
- 6, , , , , , et al. Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. HEPATOLOGY 1996; 23: 1025–1029.Direct Link:
- 7, . Joint effects of body weight and alcohol on elevated serum alanine aminotransferase in the United States population. Clin Gastroenterol Hepatol 2005; 3: 1260–1268.
- 8, , , , , , et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 444: 337–342.
- 9, , . Effect of alcohol consumption on diabetes mellitus: a systematic review. Ann Intern Med 2004; 140: 211–219.
- 10, , , , , . Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial. JAMA 2002; 287: 2559–2562.
- 11, , , , , , et al. Dietary pattern, inflammation, and incidence of type 2 diabetes in women. Am J Clin Nutr 2005; 82: 675–684; quiz 714–675.
- 12Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988–94. Hyattsville, MD: National Center for Health Statistics; 1994.
- 13, , , , , . Prevalence of fatty liver in children and adolescents. Pediatrics 2006; 118: 1388–1393.
- 14, , , , . Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients. Am J Gastroenterol 1999; 94: 3010–3014.Direct Link:
- 15, , . Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology. J Hepatol 2001; 35: 195–199.
- 16, , , , , , et al. Liver fibrosis in overweight patients. Gastroenterology 2000; 118: 1117–1123.
- 17, . Defining nonalcoholic fatty liver disease: implications for epidemiologic studies. Gastroenterology 2003; 124: 248–250.
- 18, , . The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003; 98: 960–967.Direct Link:
- 19, . Elevated AST or ALT to nonalcoholic fatty liver disease: accurate predictor of disease prevalence? Am J Gastroenterol 2003; 98: 955–956.Direct Link:
- 20, , , , , , et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002; 137: 1–10.
- 21, , , , . Intake of beer, wine and spirits and risk of heavy drinking and alcoholic cirrhosis. Biol Res 2004; 37: 195–200.
- 22, . Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2005; 128: 24–32.
- 23, , , , , , et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005; 143: 722–728.
- 24. Nonalcoholic steatohepatitis and the metabolic syndrome. Am J Med Sci 2005; 330: 326–335.
- 25, , , , , , et al. Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis 2004; 175: 117–123.
- 26, , , , . Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 1993; 341: 454–457.
- 27, , , , , , et al. Diagnostic and therapeutic implications of relationships between fasting, 2-hour postchallenge plasma glucose and hemoglobin a1c values. Arch Intern Med 2004; 164: 1627–1632.
- 28, , , , . Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J Clin Endocrinol Metab 2002; 87: 144–147.
- 29, , , , . Alcohol consumption and the prevalence of the Metabolic Syndrome in the US.: a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27: 2954–2959.
- 30, , , , , , et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. HEPATOLOGY 2004; 40: 1387–1395.Direct Link:
- 31, , , . One hundred consecutive hepatic biopsies in the workup of living donors for right lobe liver transplantation. Liver Transpl 2002; 8: 1114–1122.Direct Link:
- 32, , , , , , et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005; 129: 113–121.
- 33, , , , , , et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. HEPATOLOGY 2006; 44: 865–873.Direct Link:
- 34, , , , , . Light to moderate alcohol consumption is associated with lower frequency of hypertransaminasemia. Am J Gastroenterol 2007; 102: 1912–1919.Direct Link:
- 35, , , . Lower risk for alcohol-induced cirrhosis in wine drinkers. HEPATOLOGY 2002; 35: 868–875.Direct Link:
- 36. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 2004; 34: 9–19.
- 37, , . Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001; 121: 91–100.
- 38, , , , . Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women. Arch Intern Med 2003; 163: 1329–1336.
- 39, , , , , , et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001; 345: 790–797.
- 40, , , , , , et al. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr 2006; 84: 252–262.
- 41, , , , , , et al. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr 2005; 135: 1911–1917.
- 42, , , , . Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica. Am J Clin Nutr 2005; 82: 1336–1345.
- 43, , , , , . High-density lipoprotein cholesterol and alcohol consumption in US white and black adults: data from NHANES II. Am J Public Health 1993; 83: 811–816.
- 44, , , , . Intake of macronutrients as predictors of 5-y changes in waist circumference. Am J Clin Nutr 2006; 84: 789–797.
- 45, , , . Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures. Liver Int 2006; 26: 856–863.Direct Link:
- 46, , , , , , et al. Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults. Diabet Med 2005; 22: 1141–1145.Direct Link:
- 47, , , , , , et al. Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of Taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults. J Clin Gastroenterol 2006; 40: 745–752.

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