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An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-ᆇ

  1. Benjamin D. Cosgrove1,3,4,
  2. Connie Cheng5,
  3. Justin R. Pritchard2,3,
  4. Donna B. Stolz6,
  5. Douglas A. Lauffenburger1,2,3,4,
  6. Linda G. Griffith1,4,§,*

Article first published online: 24 MAR 2008

DOI: 10.1002/hep.22335

Issue

Hepatology

Hepatology

Volume 48, Issue 1, pages 276–288, July 2008

Additional Information

How to Cite

Cosgrove, B. D., Cheng, C., Pritchard, J. R., Stolz, D. B., Lauffenburger, D. A. and Griffith, L. G. (2008), An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-α. Hepatology, 48: 276–288. doi: 10.1002/hep.22335

Author Information

  1. 1

    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA

  2. 2

    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA

  3. 3

    Department of Cell Decision Processes Center, Massachusetts Institute of Technology, Cambridge, MA

  4. 4

    Department of Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA

  5. 5

    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA

  6. 6

    Departments of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA

  1. §

    fax: 617-253-2400.

*Dept. of Biological Engineering, M.I.T., Room 16-429, 77 Massachusetts Avenue, Cambridge, MA 02139

  1. †

    Animal Experimentation Statement: All animals received humane care according to the criteria outlined in the “Guide for the Care and Use of Laboratory Animals” prepared by the National Academy of Sciences and published by the NIH (NIH publication 86–23).

  2. ‡

    Potential conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 20 JUN 2008
  2. Article first published online: 24 MAR 2008
  3. Accepted manuscript online: 24 MAR 2008 12:00AM EST
  4. Manuscript Accepted: 11 MAR 2008
  5. Manuscript Received: 19 OCT 2007

Funded by

  • National Institutes of Health (NIH). Grant Number: P50-GM68762
  • DoD Institute for Collaborative Biotechnologies
  • Massachusetts Institute of Technology (MIT) Biotechnology Process Engineering Center
  • MIT Center for Environmental Health Sciences. Grant Numbers: NIH U19ES011399, NIH CA76541
  • Whitaker Foundation Graduate Fellowship

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