• 1
    Dragani TA. 10 Years of mouse cancer modifier loci: human relevance. Cancer Res 2003; 63: 30113018.
  • 2
    Gariboldi M, Manenti G, Canzian F, Falvella FS, Pierotti MA, Della Porta G, et al. Chromosome mapping of murine susceptibility loci to liver carcinogenesis. Cancer Res 1993; 53: 209211.
  • 3
    Dragani TA, Manenti G, Della Porta G. Genetic susceptibility to murine hepatocarcinogenesis is associated with high growth rate of NDEA-initiated hepatocytes. J Cancer Res Clin Oncol 1987; 113: 223229.
  • 4
    Della Porta G, Capitano J, Parmi L, Colnaghi MI. Urethan carcinogenesis in newborn, suckling, and adult mice of C57BL, C3H, BC3F1, C3Hf and SWR strains. Tumori 1967; 53: 81102.
  • 5
    Dragani TA, Manenti G, Della Porta G. Quantitative analysis of genetic susceptibility to liver and lung carcinogenesis in mice. Cancer Res 1991; 51: 62996303.
  • 6
    Fernando RC, Nair J, Barbin A, Miller JA, Bartsch H. Detection of 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine by immunoaffinity/32P-postlabelling in liver and lung DNA of mice treated with ethyl carbamate (urethane) or its metabolites. Carcinogenesis 1996; 17: 17111718.
  • 7
    Manenti G, Gariboldi M, Fiorino A, Zedda AI, Pierotti MA, Dragani TA. Pas1 is a common lung cancer susceptibility locus in three mouse strains. Mamm Genome 1997; 8: 801809.
  • 8
    Berger AC, Alexander HR, Tang G, Wu PS, Hewitt SM, Turner E, et al. Endothelial monocyte activating polypeptide II induces endothelial cell apoptosis and may inhibit tumor angiogenesis. Microvasc Res 2000; 60: 7080.
  • 9
    Shen R, Fan JB, Campbell D, Chang W, Chen J, Doucet D, et al. High-throughput SNP genotyping on universal bead arrays. Mutat Res 2005; 573: 7082.
  • 10
    Broman KW, Wu H, Sen S, Churchill GA. R/qtl: QTL mapping in experimental crosses. Bioinformatics 2003; 19: 889890.
  • 11
    Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics 1995; 139: 14211428.
  • 12
    Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 1994; 138: 963971.
  • 13
    Haley CS, Knott SA. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 1992; 69: 315324.
  • 14
    Wright GW, Simon RM. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 2003; 19: 24482455.
  • 15
    De Miglio MR, Canzian F, Pascale RM, Simile MM, Muroni MR, Calvisi D, et al. Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10. Cancer Res 1999; 59: 46514657.
  • 16
    Fujiwara Y, Monden M, Mori T, Nakamura Y, Emi M. Frequent multiplication of the long arm of chromosome 8 in hepatocellular carcinoma. Cancer Res 1993; 53: 857860.
  • 17
    Wong N, Lai P, Lee SW, Fan S, Pang E, Liew CT, et al. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis. Am J Pathol 1999; 154: 3743.
  • 18
    Okamoto H, Yasui K, Zhao C, Arii S, Inazawa J. PTK2 and EIF3S3 genes may be amplification targets at 8q23–q24 and are associated with large hepatocellular carcinomas. HEPATOLOGY 2003; 38: 12421249.
  • 19
    Ogawa K, Osanai M, Obata M, Ishizaki K, Kamiya K. Gain of chromosomes 15 and 19 is frequent in both mouse hepatocellular carcinoma cell lines and primary tumors, but loss of chromosomes 4 and 12 is detected only in the cell lines. Carcinogenesis 1999; 20: 20832088.
  • 20
    Bilger A, Bennett LM, Carabeo RA, Chiaverotti TA, Dvorak C, Liss KM, et al. A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines. Genetics 2004; 167: 859866.
  • 21
    Lee GH, Bennett LM, Carabeo RA, Drinkwater NR. Identification of hepatocarcinogen-resistance genes in DBA/2 mice. Genetics 1995; 139: 387395.
  • 22
    Bell LA, Ryan KM. Life and death decisions by E2F-1. Cell Death Differ 2004; 11: 137142.
  • 23
    Harper JW, Elledge SJ. Skipping into the E2F1-destruction pathway. Nat Cell Biol 1999; 1: E5E7.
  • 24
    Conner EA, Lemmer ER, Omori M, Wirth PJ, Factor VM, Thorgeirsson SS. Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis. Oncogene 2000; 19: 50545062.
  • 25
    Dragani TA, Canzian F, Manenti G, Pierotti MA. Hepatocarcinogenesis: a polygenic model of inherited predisposition to cancer. Tumori 1996; 82: 15.
  • 26
    De Munter HK, Den Engelse L, Emmelot P. Studies on lung tumors. IV. Correlations between [3H]thymidine labelling of lung and liver cells and tumor formation in GRS/A and C3Hf/A male mice following administration of dimethylnitrosamine. Chem Biol Interactions 1979; 24: 299316.
  • 27
    Hanigan MH, Kemp CJ, Ginsler JJ, Drinkwater NR. Rapid growth of preneoplastic lesions in hepatocarcinogen-sensitive C3H/HeJ male mice relative to C57BL/6J male mice. Carcinogenesis 1988; 9: 885890.
  • 28
    Ruehl M, Erben U, Schuppan D, Wagner C, Zeller A, Freise C, et al. The elongated first fibronectin type III domain of collagen XIV is an inducer of quiescence and differentiation in fibroblasts and preadipocytes. J Biol Chem 2005; 280: 3853738543.
  • 29
    Shih WL, Yu MW, Chen PJ, Yeh SH, Lo MT, Chang HC, et al. Localization of a susceptibility locus for hepatocellular carcinoma to chromosome 4q in a hepatitis B hyperendemic area. Oncogene 2006; 25: 32193224.
  • 30
    Condamine H, Custer RP, Mintz B. Pure-strain and genetically mosaic liver tumors histochemically identified with the beta-glucuronidase marker in allophenic mice. Proc Natl Acad Sci U S A 1971; 68: 20322036.
  • 31
    Tsukamoto T, Inada K, Fukami H, Yamamoto M, Tanaka H, Kusakabe M, et al. Mouse strain susceptibility to diethylnitrosamine induced hepatocarcinogenesis is cell autonomous whereas sex-susceptibility is due to the micro-environment: analysis with C3H BALB / c sexually chimeric mice. Jpn J Cancer Res 2000; 91: 665673.
  • 32
    Germolec DR, Maronpot RR, Ackermann MF, Vore SJ, Dittrich K, Rosenthal GJ, et al. Lack of a relationship between immune function and chemically induced hepatocarcinogenesis in B6C3F1 mice. Cancer Immunol Immunother 1988; 27: 121127.