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Hereditary hemochromatosis in the post-HFE era†
Article first published online: 16 JUL 2008
Copyright © 2008 American Association for the Study of Liver Diseases
Volume 48, Issue 3, pages 991–1001, September 2008
How to Cite
Olynyk, J. K., Trinder, D., Ramm, G. A., Britton, R. S. and Bacon, B. R. (2008), Hereditary hemochromatosis in the post-HFE era. Hepatology, 48: 991–1001. doi: 10.1002/hep.22507
Potential conflict of interest: Nothing to report.
- Issue published online: 27 AUG 2008
- Article first published online: 16 JUL 2008
- Accepted manuscript online: 16 JUL 2008 12:00AM EST
- Manuscript Accepted: 23 JUN 2008
- Manuscript Received: 17 APR 2008
- National Health and Medical Research Council of Australia. Grant Numbers: 404021, 513761, 339400, 241913
- National Institutes of Health. Grant Number: DK41816
Following the discovery of the HFE gene in 1996 and its linkage to the iron overload disorder hereditary hemochromatosis (HH) there have been profound developments in our understanding of the pathogenesis of the biochemical and clinical manifestations of a number of iron overload disorders. This article provides an update of recent developments and key issues relating to iron homeostasis and inherited disorders of iron overload, with emphasis on HFE-related HH, and is based on the content of the American Association for the Study of Liver Diseases Single-Topic Conference entitled “Hemochromatosis: What has Happened After HFE?” which was held at the Emory Convention Center in Atlanta, September 7-9, 2007. (HEPATOLOGY 2008;48:991–1001.)