Hereditary hemochromatosis in the post-HFE era

Authors

  • John K. Olynyk,

    Corresponding author
    1. School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    2. The Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia
    3. Western Australian Institute for Medical Research, Nedlands, Western Australia, Australia
    • School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, P.O. Box 480, Fremantle 6959, Western Australia, Australia
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    • fax: 618-9431 2977.

  • Debbie Trinder,

    1. School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    2. Western Australian Institute for Medical Research, Nedlands, Western Australia, Australia
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  • Grant A. Ramm,

    1. The Hepatic Fibrosis Group, The Queensland Institute of Medical Research, Brisbane, Australia
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  • Robert S. Britton,

    1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, MO
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  • Bruce R. Bacon

    1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, MO
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  • Potential conflict of interest: Nothing to report.

Abstract

Following the discovery of the HFE gene in 1996 and its linkage to the iron overload disorder hereditary hemochromatosis (HH) there have been profound developments in our understanding of the pathogenesis of the biochemical and clinical manifestations of a number of iron overload disorders. This article provides an update of recent developments and key issues relating to iron homeostasis and inherited disorders of iron overload, with emphasis on HFE-related HH, and is based on the content of the American Association for the Study of Liver Diseases Single-Topic Conference entitled “Hemochromatosis: What has Happened After HFE?” which was held at the Emory Convention Center in Atlanta, September 7-9, 2007. (HEPATOLOGY 2008;48:991–1001.)

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