Viral Hepatitis

You have full text access to this OnlineOpen article

Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen–negative chronic hepatitis B virus infection?†

  1. George V. Papatheodoridis1,‡,*,
  2. Emanuel K. Manesis1,
  3. Spilios Manolakopoulos1,
  4. Ioannis S. Elefsiniotis2,
  5. John Goulis3,
  6. John Giannousis1,
  7. Antonios Bilalis4,
  8. Georgia Kafiri5,
  9. Dimitrios Tzourmakliotis4,
  10. Athanasios J. Archimandritis1

Article first published online: 10 JUL 2008

DOI: 10.1002/hep.22518

Issue

Hepatology

Hepatology

Volume 48, Issue 5, pages 1451–1459, November 2008

Additional Information

How to Cite

Papatheodoridis, G. V., Manesis, E. K., Manolakopoulos, S., Elefsiniotis, I. S., Goulis, J., Giannousis, J., Bilalis, A., Kafiri, G., Tzourmakliotis, D. and Archimandritis, A. J. (2008), Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen–negative chronic hepatitis B virus infection?. Hepatology, 48: 1451–1459. doi: 10.1002/hep.22518

Author Information

  1. 1

    2nd Department of Internal Medicine, Athens University Medical School, “Hippokration” General Hospital of Athens, Athens, Greece

  2. 2

    University Department of Internal Medicine, “Helena Venizelou” Hospital, Athens, Greece

  3. 3

    4th Department of Medicine, Aristotelian University of Thessaloniki, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece

  4. 4

    Department of Gastroenterology, Polyclinic General Hospital of Athens, Athens, Greece

  5. 5

    Department of Pathology, “Hippokration” General Hospital of Athens, Athens, Greece

  1. ‡

    fax: (30)-210-7706871

*2nd Department of Internal Medicine, Athens University Medical School, Hippokration General Hospital of Athens, 114 Vas. Sophias Ave., 115 27 Athens, Greece

  1. †

    Potential conflict of interest: Dr. Papatheodoridis is a consultant for, advises, is on the speakers' bureau of, and received grants from Gilead Sciences, Roche, and Novartis. He is a consultant and advises Bristol-Myers Squibb. Dr. Manolakopoulos is a consultant, advises, is on the speakers' bureau of, and received grants from Gilead. He is a consultant for and received grants from Roche. He is a consultant for, advises, and received grants from Schering-Plough. He advises Bristol-Myers Squibb.

Publication History

  1. Issue published online: 28 OCT 2008
  2. Article first published online: 10 JUL 2008
  3. Accepted manuscript online: 10 JUL 2008 12:00AM EST
  4. Manuscript Accepted: 29 JUN 2008
  5. Manuscript Received: 13 FEB 2008

Funded by

  • Center for Control and Prevention of Diseases, Ministry of Health, Greece

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (163K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    C. M. N. Croagh, S. J. Bell, S. Locarnini, P. V. Desmond, Assessment of chronic hepatitis B: the importance of hepatitis B virus DNA testing, Internal Medicine Journal, 2012, 42, 2
    Direct Link:
  2. 2
    George V. Papatheodoridis, Spilios Manolakopoulos, Yun-Fan Liaw, Anna Lok, Follow-up and indications for liver biopsy in HBeAg-negative chronic hepatitis B virus infection with persistently normal ALT: A systematic review, Journal of Hepatology, 2012,

    CrossRef

  3. 3
    Catherine M. N. Croagh, Sally J. Bell, Paul V. Desmond, Methodological considerations in studying natural history of HBeAg-negative and -positive chronic hepatitis B: authors' reply, Liver International, 2012, 32, 4
    Direct Link:
  4. 4
    Y.-C. Chen, S.-F. Huang, C.-M. Chu, Y.-F. Liaw, Serial HBV DNA levels in patients with persistently normal transaminase over 10 years following spontaneous HBeAg seroconversion, Journal of Viral Hepatitis, 2012, 19, 2
    Direct Link:
  5. 5
    W. Chotiyaputta, B. Degertekin, B. J. McKenna, N. Samala, R. J. Fontana, A. S. F. Lok, Characteristics of chronic hepatitis B patients who underwent liver biopsies, Journal of Viral Hepatitis, 2011, 18, 11
    Direct Link:
  6. 6
    Henry Lik-Yuen Chan, Jidong Jia, Chronic hepatitis B in Asia—new insights from the past decade, Journal of Gastroenterology and Hepatology, 2011, 26,
    Direct Link:
  7. 7
    F. M. Sanai, A. Helmy, K. I. Bzeizi, M. A. Babatin, A. Al-Qahtani, H. A. Al-Ashgar, A. S. Al-Mdani, A. Al-Akwaa, S. Almutharea, M. Q. Khan, A. S. Alghamdi, T. Farah, W. Al-Hamoudi, M. Saadeh, A. A. Abdo, Discriminant value of serum HBV DNA levels as predictors of liver fibrosis in chronic hepatitis B, Journal of Viral Hepatitis, 2011, 18, 7
    Direct Link:
  8. 8
    Tony Andreani, HBV-carriers: When is monitoring and surveillance sufficient? (point of view), Clinics and Research in Hepatology and Gastroenterology, 2011, 35, 12, 813

    CrossRef

  9. 9
    Henry Lik-Yuen Chan, Alex Thompson, Michelle Martinot-Peignoux, Teerha Piratvisuth, Markus Cornberg, Maurizia Rossana Brunetto, Hans L. Tillmann, Jia-Horng Kao, Ji-Dong Jia, Heiner Wedemeyer, Stephen Locarnini, Harry L.A. Janssen, Patrick Marcellin, Hepatitis B surface antigen quantification: Why and how to use it in 2011 – A core group report, Journal of Hepatology, 2011, 55, 5, 1121

    CrossRef

  10. 10
    S. C. Pezzano, C. Torres, H. A. Fainboim, M. B. Bouzas, T. Schroder, S. F. Giuliano, S. Paz, E. Alvarez, R. H. Campos, V. A. Mbayed, Hepatitis B virus in Buenos Aires, Argentina: genotypes, virological characteristics and clinical outcomes, Clinical Microbiology and Infection, 2011, 17, 2
    Direct Link:
  11. 11
    Chih-Lin Lin, Tai-Chung Tseng, Tung-Hung Su, Chun-Jen Liu, Pei-Jer Chen, Ming-Yang Lai, Ding-Shinn Chen, Jia-Horng Kao, Host genetic variants and hepatitis B virologic features in HBeAg-negative hepatitis B carriers with long-term biochemical remission, Hepatology International, 2011, 6, 3, 598

    CrossRef

  12. 12
    I-Cheng Lee, Yi-Hsiang Huang, Che-Chang Chan, Teh-Ia Huo, Chi-Jen Chu, Chiung-Ru Lai, Pui-Ching Lee, Chien-Wei Su, Jaw-Ching Wu, Han-Chieh Lin, Shou-Dong Lee, Impact of body mass index and viral load on liver histology in hepatitis B e antigen-negative chronic hepatitis B, Clinical Nutrition, 2011, 30, 5, 647

    CrossRef

  13. 13
    C Fotiadou, E Lazaridou, D Ioannides, Safety of anti-tumour necrosis factor-α agents in psoriasis patients who were chronic hepatitis B carriers: a retrospective report of seven patients and brief review of the literature, Journal of the European Academy of Dermatology and Venereology, 2011, 25, 4
    Direct Link:
  14. 14
    L. Castéra, P.-H. Bernard, B. Le Bail, J. Foucher, P. Trimoulet, W. Merrouche, P. Couzigou, V. de Lédinghen, Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers, Alimentary Pharmacology & Therapeutics, 2011, 33, 4
    Direct Link:
  15. 15
    T. Berg, Y. Benhamou, J. L. Calleja, M. Levrero, W. Johnson, N. Ellis, A survey of chronic hepatitis B patient management practices in the European Union, Journal of Viral Hepatitis, 2010, 17, 9
    Direct Link:
  16. 16
    G Brook, J Main, M Nelson, S Bhagani, E Wilkins, C Leen, M Fisher, Y Gilleece, R Gilson, A Freedman, R Kulasegaram, K Agarwal, C Sabin, C Deacon-Adams, British HIV Association guidelines for the management of coinfection with HIV-1 and hepatitis B or C virus 2010, HIV Medicine, 2010, 11, 1
    Direct Link:
  17. 17
    Mamun Al-Mahtab, Salimur Rahman, Sheikh Mohammad Fazle Akbar, Mohammad Kamal, Mohammad Sakirul Islam Khan, Clinical use of liver biopsy for the diagnosis and management of inactive and asymptomatic hepatitis B virus carriers in Bangladesh, Journal of Medical Virology, 2010, 82, 8
    Direct Link:
  18. 18
    I-Cheng Lee, Yi-Hsiang Huang, Che-Chang Chan, Teh-Ia Huo, Chi-Jen Chu, Chiung-Ru Lai, Pui-Ching Lee, Chien-Wei Su, Hung-Hsu Hung, Jaw-Ching Wu, Han-Chieh Lin, Shou-Dong Lee, Correlation between clinical indication for treatment and liver histology in HBeAg-negative chronic hepatitis B: a novel role of α-fetoprotein, Liver International, 2010, 30, 8
    Direct Link:
  19. 19
    Maurizia Rossana Brunetto, Filippo Oliveri, Piero Colombatto, Francesco Moriconi, Pietro Ciccorossi, Barbara Coco, Veronica Romagnoli, Beatrice Cherubini, Giovanna Moscato, Anna Maria Maina, Daniela Cavallone, Ferruccio Bonino, Hepatitis B Surface Antigen Serum Levels Help to Distinguish Active From Inactive Hepatitis B Virus Genotype D Carriers, Gastroenterology, 2010, 139, 2, 483

    CrossRef

  20. 20
    Joseph K. Lim, Walid S. Ayoub, Mindie H. Nguyen, Histologic Disease in Patients with Chronic Hepatitis B, High HBV DNA, and Normal Alanine Aminotransferase Levels, Current Hepatitis Reports, 2010, 9, 2, 65

    CrossRef

  21. 21
    Catherine M. N. Croagh, Sally J. Bell, John Slavin, Yu X. G. Kong, Robert Y Chen, Stephen Locarnini, Paul V Desmond, Increasing hepatitis B viral load is associated with risk of significant liver fibrosis in HBeAg-negative but not HBeAg-positive chronic hepatitis B, Liver International, 2010, 30, 8
    Direct Link:
  22. 22
    Chia–Ming Chu, Yi–Cheng Chen, Dar–In Tai, Yun–Fan Liaw, Level of Hepatitis B Virus DNA in Inactive Carriers With Persistently Normal Levels of Alanine Aminotransferase, Clinical Gastroenterology and Hepatology, 2010, 8, 6, 535

    CrossRef

  23. 23
    William Graham Earnshaw Cooksley, Natural history of chronic hepatitis B: extending the REVEAL study, Liver International, 2010, 30, 8
    Direct Link:
  24. 24
    L.Y. Lin, V.W.S. Wong, H.J. Zhou, H.Y. Chan, H.L. Gui, S.M. Guo, H. Wang, L. Huang, S.S. Bao, Q. Xie, H.L.Y. Chan, Relationship between serum hepatitis B virus DNA and surface antigen with covalently closed circular DNA in HBeAg-negative patients, Journal of Medical Virology, 2010, 82, 9
    Direct Link:
  25. 25
    George V. Papatheodoridis, Spilios Manolakopoulos, EASL clinical practice guidelines on the management of chronic hepatitis B: The need for liver biopsy, Journal of Hepatology, 2009, 51, 1, 226

    CrossRef

  26. 26
    Henry Lik–Yuen Chan, Grace Lai–Hung Wong, Chi–Hang Tse, Angel Mei–Ling Chim, Karen Kar–Lum Yiu, Hoi–Yun Chan, Joseph Jao–Yiu Sung, Vincent Wai–Sun Wong, Hepatitis B Virus Genotype C Is Associated With More Severe Liver Fibrosis Than Genotype B, Clinical Gastroenterology and Hepatology, 2009, 7, 12, 1361

    CrossRef

  27. 27
    Hans Tillmann, Keyur Patel, John McHutchison, Hepatitis B virus viral load and treatment decision, Hepatology, 2009, 49, 2
    Direct Link:
  28. 28
    Dar-In Tai, Shi-Ming Lin, I-Shyan Sheen, Chia-Ming Chu, Deng-Yn Lin, Yun-Fan Liaw, Long-term outcome of hepatitis B e antigen–negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time, Hepatology, 2009, 49, 6
    Direct Link:
  29. 29
    Emanuel K. Manesis, The natural history of chronic HBV infection, Current Hepatitis Reports, 2009, 8, 1, 10

    CrossRef

View Full Article (HTML) Get PDF (163K)