These authors contributed equally to this study.
Hepatobiliary Malignancies
You have full text access to this OnlineOpen article
Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma†
Article first published online: 19 SEP 2008
DOI: 10.1002/hep.22638
Copyright © 2008 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Bai, D.-S., Dai, Z., Zhou, J., Liu, Y.-K., Qiu, S.-J., Tan, C.-J., Shi, Y.-H., Huang, C., Wang, Z., He, Y.-F. and Fan, J. (2009), Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma. Hepatology, 49: 460–470. doi: 10.1002/hep.22638
- †
Potential conflict of interest: Nothing to report.
- ‡
These authors contributed equally to this study.
- §
fax: (86)-21-64037181
Publication History
- Issue published online: 28 JAN 2009
- Article first published online: 19 SEP 2008
- Accepted manuscript online: 19 SEP 2008 12:00AM EST
- Manuscript Accepted: 11 SEP 2008
- Manuscript Received: 19 FEB 2008
Funded by
- State 863 High Technology R&D Project of China. Grant Number: 2007AA02Z479
- Program for Outstanding Medical Academic Leader. Grant Number: LJ06004
- Specialized Research Fund for the Doctoral Program of Higher Education. Grant Number: 20070246112
Reference
- 1, , , . Global cancer statistics, 2002. CA. Cancer J Clin 2005; 55: 74–108.
- 2. Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 1988; 61: 1942–1956.
- 3, , , , , , et al. Hepatitis C virus infection is an additive risk factor for development of hepatocellular carcinoma in patients with cirrhosis. J Hepatol 1991; 12: 367–371.
- 4, , , , , , et al. HCV-associated hepatocellular carcinoma without cirrhosis. J Hepatol 1996; 24: 277–285.
- 5. Hepatitis C virus and hepatocellular carcinoma. Sem Liver Dis 1999; 19: 263–269.
- 6, , , , , . Liver transplantation for hepatocellular carcinoma. Ann Surg 2001; 233: 652–659.
- 7, , , . The outcome of liver transplantation in patients with hepatocellular carcinoma in the United States between 1988 and 2001: 5-year survival has improved significant with time. J Clin Oncol 2003; 21: 4329.
- 8, , , , , , et al. Predictors of long-term survival after liver transplantation for hepatocellular carcinoma. Am J Gastroenterol 2005; 100: 2708–2716.Direct Link:
- 9, , , , , , et al. Recurrent hepatocellular carcinoma after transplantation: use of a pathological score on explanted livers to predict recurrence. Liver Transpl 2007; 13: 543–551.
- 10, , , , , , et al. Accurate qualitative and quantitative proteomic analysis of clinical hepatocellular carcinoma using laser capture microdissection coupled with isotope-coded affinity tag and two-dimensional liquid chromatography mass spectrometry. Mol Cell Proteomics 2004; 3: 399–409.
- 11, , , , , . Characterization of vascular protein expression patterns in cerebral ischemia/reperfusion using laser capture microdissection and ICAT-nanoLC-MS/MS. FASEB J 2005; 19: 1809–1821.
- 12, , , , , , et al. Identification and analysis of altered alpha1,6-fucosylated glycoproteins associated with hepatocellular carcinoma metastasis. Proteomics 2006; 6: 5857–5867.
- 13, , , , , , et al. From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis. Mol Cell Proteomics 2004; 3: 73–81.
- 14, , , , , , et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. HEPATOLOGY 2001; 33: 1394–1403.
- 15, , , , , , et al. Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics. J Cancer Res Clin Oncol 2004; 130: 460–468.
- 16, , , , , , et al. Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escape. Gastroenterol 2005; 129: 1187–1197.
- 17, , . An approach to correlate tandem mass-spectral data of peptides with amino-acid-sequences in a protein database. J Am Soc Mass Spectr 1994; 5: 976–989.
- 18, , , . Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal Chem 2002; 74: 5383–5392.
- 19, , , . A statistical model for identifying proteins by tandem mass spectrometry. Anal Chem 2003; 75: 4646–4658.
- 20, , , . Automated statistical analysis of protein abundance ratios from data generated by stable-isotope dilution and tandem mass spectrometry. Anal Chem 2003; 75: 6648–6657.
- 21, , , , , , et al. Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. HEPATOLOGY 2008; 48: 497–507.
- 22, , , , , , et al. Liver transplantation and recurrent hepatocellular carcinoma: predictive value of nodule size in a retrospective and explant study. Transplantation 2006; 81: 1532–1541.
- 23, , , , , , et al. Proteomic analysis on metastasis-associated proteins of human hepatocellular carcinoma tissues. J Cancer Res Clin Oncol 2005; 132: 92–98.
- 24, , , , , , et al. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 2003; 9: 416–423.
- 25, , , , , . Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol 1999; 17: 994–999.
- 26, , , , , , et al. Expression and growth-promoting effect of adult T-cell leukemia-derived factor: a human thioredoxin homologue in hepatocellular carcinoma. Cancer 1992; 69: 2091–2097.
- 27, , . High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells. Cancer Res 1995; 55: 675–680.
- 28, , , , , . Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia. Anticancer Res 1996; 16: 3459–3466.
- 29, , , . Thioredoxin, a gene found overexpressed in human cancer, inhibitis apoptosis in vitro and in vivo. Cancer Res 1997; 57: 5162–5167.
- 30, . Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14:18). Nature 1991; 349: 254–256.
- 31, . Nuclear shift of hnRNP K protein in neoplasms and other states of enhanced cell proliferation. Br J Cancer 2003; 89: 1493–1501.
- 32, , , , . The calpain system. Physiol Rev 2003; 83: 731–801.
- 33, , . Structure of the mouse calpain small subunit gene. Biochim Biophys Acta 1998; 1388: 247–252.
- 34, , , , , . Conditional disruption of ubiquitous calpains in the mouse. Genesis 2006; 44: 297–303.
- 35, , , . Beta1-integrin-mediated T-cell adhesion and cell spreading are regulated by calpain. Exp Cell Res 2000; 261: 260–270.
- 36, , , , , , et al. Calpain regulates actin remodeling during cell spreading. J Cell Biol 1998; 141: 647–662.
- 37, , , , , , et al. Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol 2004; 6: 977–983.
- 38, . Role of calpain in skeletal-muscle protein degradation. Proc Natl Acad Sci U S A 1998; 95: 12100–12105.

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8)