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Liver Biology/Pathobiology
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Hepatic function is preserved in the absence of mature microRNAs†
Article first published online: 26 SEP 2008
DOI: 10.1002/hep.22656
Copyright © 2008 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Hand, N. J., Master, Z. R., Le Lay, J. and Friedman, J. R. (2009), Hepatic function is preserved in the absence of mature microRNAs. Hepatology, 49: 618–626. doi: 10.1002/hep.22656
- †
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 28 JAN 2009
- Article first published online: 26 SEP 2008
- Accepted manuscript online: 26 SEP 2008 12:00AM EST
- Manuscript Accepted: 16 SEP 2008
- Manuscript Received: 11 JUL 2008
Funded by
- Fred and Suzanne Biesecker Pediatric Liver Center
- Children's Digestive Health and Nutrition Foundation
- National Institutes of Health. Grant Number: K08DK070881
References
- 1. microRNAs: tiny regulators with great potential. Cell 2001; 107: 823–826.
- 2. The functions of animal microRNAs. Nature 2004; 431: 350–355.
- 3, , , . Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001; 409: 363–366.
- 4, , , , , . A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2001; 293: 834–838.
- 5, , , , , . Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C elegans. Genes Dev 2001; 15: 2654–2659.
- 6, . A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 2001; 293: 2269–2271.
- 7, . Piecing together the mosaic of early mammalian development through microRNAs. J Biol Chem 2008; 283: 9505–9508.
- 8. Everything you wanted to know about small RNA but were afraid to ask. Lab Invest 2008; 88: 569–578.
- 9
- 10, , , , , , et al. Silencing of microRNAs in vivo with “antagomirs.” Nature 2005; 438: 685–689.
- 11, , , , , . Identification of tissue-specific microRNAs from mouse. Curr Biol 2002; 12: 735–739.
- 12, , , , , , et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006; 3: 87–98.
- 13, , , , , , et al. Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem 2006; 99: 671–678.Direct Link:
- 14, , . Positive and negative modulation of viral and cellular mRNAs by liver-specific microRNA miR-122. Cold Spring Harb Symp Quant Biol 2006; 71: 369–376.
- 15, , , , , , et al. Dicer is essential for mouse development. Nat Genet 2003; 35: 215–217.
- 16, , , , , , et al. T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med 2005; 201: 1367–1373.
- 17, , , , , , et al. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci 2008; 28: 4878–4887.
- 18, , , , , , et al. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci 2008; 28: 4322–4330.
- 19, , , , , , et al. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet 2006; 38: 356–362.
- 20, , , , , . MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes 2007; 56: 2938–2945.
- 21, , , , . Foxa2 integrates the transcriptional response of the hepatocyte to fasting. Cell Metab 2005; 2: 141–148.
- 22, , , , . A model based background adjustment for oligonucleotide expression arrays. Johns Hopkins University Department of Biostatistics Working Papers, 2004.
- 23, , . Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001; 98: 5116–5121.
- 24, , , , , , et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005; 102: 15545–15550.
- 25, , , , , , et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34: 267–273.
- 26, , , , . In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat Methods 2006; 3: 27–29.
- 27, , , , , , et al. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature 2005; 434: 338–345.
- 28, . The p53 pathway: positive and negative feedback loops. Oncogene 2005; 24: 2899–2908.
- 29, , , , , , et al. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 2008; 451: 1125–1129.
- 30, , , , , , et al. Regulation of the germinal center response by microRNA-155. Science 2007; 316: 604–608.
- 31, , , , , , et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 2007; 129: 303–317.
- 32, , , , , , et al. Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med 2007; 204: 1553–1558.
- 33, , . Silencing by imprinted noncoding RNAs: is transcription the answer? Trends Genet 2007; 23: 284–292.
- 34, , , , , , et al. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev 2005; 19: 489–501.
- 35, , , , , , et al. Clusters of internally primed transcripts reveal novel long noncoding RNAs. PLoS Genet 2006; 2: e37.
- 36, , , , , , et al. A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. Cancer Res 2008; 68: 2570–2575.
- 37, , , , . Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth in vivo. Cancer Res 2001; 61: 8564–8568.