Article first published online: 13 NOV 2008
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 49, Issue 3, pages 960–968, March 2009
How to Cite
Guo, J., Loke, J., Zheng, F., Hong, F., Yea, S., Fukata, M., Tarocchi, M., Abar, O. T., Huang, H., Sninsky, J. J. and Friedman, S. L. (2009), Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses. Hepatology, 49: 960–968. doi: 10.1002/hep.22697
Presented in abstract form as an oral presentation at the 2007 American Association for the Study of Liver Diseases Annual meeting and published in abstract form.
Potential conflict of interest: Nothing to report.
This is a corrected version of Dr. Fukata's name first published online on 13 November 2008—The corrected version appears in print.
- Issue published online: 24 FEB 2009
- Article first published online: 13 NOV 2008
- Accepted manuscript online: 13 NOV 2008 12:00AM EST
- Manuscript Accepted: 10 OCT 2008
- Manuscript Received: 6 JUL 2008
- National Institutes of Health. Grant Number: RO1DK56631
- Celera Diagnostics
Additional Supporting Information may be found in the online version of this article.
|hepa_22697_sm_SupFig1.tif||541K||Supplemental Figure 1 Legend. Expression of exogenous human TLR4 in LX-2 or mouse TLR4 -/- HSCs. LX-2 cells or mouse TLR4-/- HSC lines were transiently or stably reconstituted with human TLR4 cDNAs. The protein expression and the localization of exogenous human TLR4 proteins following reconstitution were determined by immunopercipitation and direct immunofluorescence, respectively, using anti-Flag monoclonal antibodyies. A&B: Western blot analysis of TLR4-Flag proteins in LX-2 cells (A) and mouse stellate cell lines (B) after reconstitution of TLR4. C&D; E&F: Immunofluorescence detection of TRL4-Flag protein in LX-2 cells (C&D) and mouse HSCs (E&F) after transfection of exogenous TLR4 or control cDNAs. Cell surface localization of Flag-TLR4 protein is suggested by the appearance of TLR4 staining in LX-2 cells (C) and TLR4-/- mouse stellate cells (E) transfected with human TLR4 wild type cDNA but not in LX-2 cells (D) or mouse TLR4-/- HSCs (F) transfected with a LacZ-expressing control vector.|
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