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Locating the stem cell niche and tracing hepatocyte lineages in human liver†
Article first published online: 23 DEC 2008
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 49, Issue 5, pages 1655–1663, May 2009
How to Cite
Fellous, T. G., Islam, S., Tadrous, P. J., Elia, G., Kocher, H. M., Bhattacharya, S., Mears, L., Turnbull, D. M., Taylor, R. W., Greaves, L. C., Chinnery, P. F., Taylor, G., McDonald, S. A.C., Wright, N. A. and Alison, M. R. (2009), Locating the stem cell niche and tracing hepatocyte lineages in human liver. Hepatology, 49: 1655–1663. doi: 10.1002/hep.22791
Potential conflict of interest: Nothing to report.
- Issue published online: 27 APR 2009
- Article first published online: 23 DEC 2008
- Accepted manuscript online: 23 DEC 2008 12:00AM EST
- Manuscript Accepted: 7 DEC 2008
- Manuscript Received: 6 OCT 2008
- Barts and The London Charitable Trust
Additional Supporting Information may be found in the online version of this article.
|HEP_22791_sm_SupplFig1.mp4||1578K||Supporting Figure 1. Two patches of cytochrome c oxidase-deficient hepatocytes are present (as in Fig. 7). The upper one extending left of center contains cells almost completely devoid of cytochrome c oxidase activity (so appearing totally white), presumably representing a homoplasmic mutation in the founder cell. The other patch extending from the center to bottom right is more ‘grainy’ representing a large cluster of cells with residual cytochrome c oxidase activity (brown), presumably representing a heteroplasmic mutation in the founder cell. The portal tract is the white bar running more or less parallel with the right hand margins of both patches. Rotation through 360 degrees illustrates that the patches always remain ‘attached’ the portal tract, and shows how each has a ‘pushing’ rather than an ‘infiltrative’ margin with the neighboring cytochrome c oxidase -positive hepatocytes.|
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