Additional Supporting Information may be found in the online version of this article.

HEP_22791_sm_SupplFig1.mp41578KSupporting Figure 1. Two patches of cytochrome c oxidase-deficient hepatocytes are present (as in Fig. 7). The upper one extending left of center contains cells almost completely devoid of cytochrome c oxidase activity (so appearing totally white), presumably representing a homoplasmic mutation in the founder cell. The other patch extending from the center to bottom right is more ‘grainy’ representing a large cluster of cells with residual cytochrome c oxidase activity (brown), presumably representing a heteroplasmic mutation in the founder cell. The portal tract is the white bar running more or less parallel with the right hand margins of both patches. Rotation through 360 degrees illustrates that the patches always remain ‘attached’ the portal tract, and shows how each has a ‘pushing’ rather than an ‘infiltrative’ margin with the neighboring cytochrome c oxidase -positive hepatocytes.

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