Steatohepatitis/Metabolic Liver Disease

You have full text access to this OnlineOpen article

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease†

  1. Luca Miele1,
  2. Venanzio Valenza2,‡,
  3. Giuseppe La Torre3,‡,
  4. Massimo Montalto1,‡,
  5. Giovanni Cammarota1,
  6. Riccardo Ricci4,
  7. Roberta Mascianà1,
  8. Alessandra Forgione1,
  9. Maria L. Gabrieli1,
  10. Germano Perotti2,
  11. Fabio M. Vecchio4,
  12. Gianlodovico Rapaccini1,
  13. Giovanni Gasbarrini1,
  14. Chris P. Day5,§,
  15. Antonio Grieco1,§,¶,*

Article first published online: 23 JAN 2009

DOI: 10.1002/hep.22848

Issue

Hepatology

Hepatology

Volume 49, Issue 6, pages 1877–1887, June 2009

Additional Information

How to Cite

Miele, L., Valenza, V., La Torre, G., Montalto, M., Cammarota, G., Ricci, R., Mascianà, R., Forgione, A., Gabrieli, M. L., Perotti, G., Vecchio, F. M., Rapaccini, G., Gasbarrini, G., Day, C. P. and Grieco, A. (2009), Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology, 49: 1877–1887. doi: 10.1002/hep.22848

Author Information

  1. 1

    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy

  2. 2

    Institute of Nuclear Medicine, Catholic University of Rome, Rome, Italy

  3. 3

    Institute of Public Health—Biostatistic Unit, Catholic University of Rome, Rome, Italy

  4. 4

    Institute of Pathology, Catholic University of Rome, Rome, Italy

  5. 5

    Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, UK

  1. ‡

    These authors contributed equally to this work.

  2. §

    These authors share senior authorship.

  3. fax: (39)-(0)6-35502775.

*Università Cattolica del Sacro Cuore, Facoltà di Medicina e Chirurgia “Agostino Gemelli” Istituto di Medicina Interna, Largo Agostino Gemelli 8 - 00168 Rome, Italy

  1. †

    Potential conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 28 MAY 2009
  2. Article first published online: 23 JAN 2009
  3. Accepted manuscript online: 23 JAN 2009 12:00AM EST
  4. Manuscript Accepted: 13 JAN 2009
  5. Manuscript Received: 16 SEP 2008

Funded by

  • Cofin MIUR - Università Cattolica del Sacro Cuore. Grant Number: “Linea D.1” 2004
  • Cofin MIUR, Università Cattolica del Sacro Cuore and “Istituto Toniolo Research Prize”. Grant Number: “Giovani Ricercatori” 2002

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (1034K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    Valentina Volynets, Jürgen Machann, Markus A. Küper, Ina B. Maier, Astrid Spruss, Alfred Königsrainer, Stephan C. Bischoff, Ina Bergheim, A moderate weight reduction through dietary intervention decreases hepatic fat content in patients with non-alcoholic fatty liver disease (NAFLD): a pilot study, European Journal of Nutrition, 2012,

    CrossRef

  2. 2
    Derrick E. Fouts, Manolito Torralba, Karen E. Nelson, David A. Brenner, Bernd Schnabl, Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease, Journal of Hepatology, 2012, 56, 6, 1283

    CrossRef

  3. 3
    Jianjun Liu, Dachang Wu, Ayaz Ahmed, Xinli Li, Yufang Ma, Li Tang, Dianjun Mo, Yue Ma, Yi Xin, Comparison of the Gut Microbe Profiles and Numbers Between Patients with Liver Cirrhosis and Healthy Individuals, Current Microbiology, 2012, 65, 1, 7

    CrossRef

  4. 4
    D. Compare, P. Coccoli, A. Rocco, O.M. Nardone, S. De Maria, M. Cartenì, G. Nardone, Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease, Nutrition, Metabolism and Cardiovascular Diseases, 2012, 22, 6, 471

    CrossRef

  5. 5
    Deepa Rana, Ajay Duseja, Radha K. Dhiman, Yogesh Chawla, Sunil K. Arora, Maturation defective myeloid dendritic cells in nonalcoholic fatty liver disease patients release inflammatory cytokines in response to endotoxin, Hepatology International, 2012,

    CrossRef

  6. 6
    Astrid Spruss, Giridhar Kanuri, Carolin Stahl, Stephan C Bischoff, Ina Bergheim, Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function, Laboratory Investigation, 2012,

    CrossRef

  7. 7
    Veerle Bieghs, Patrick C.N. Rensen, Marten H. Hofker, Ronit Shiri-Sverdlov, NASH and atherosclerosis are two aspects of a shared disease: Central role for macrophages, Atherosclerosis, 2012, 220, 2, 287

    CrossRef

  8. 8
    Geoffrey C. Farrell, Derrick van Rooyen, Lay Gan, Shivrakumar Chitturi, NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications, Gut and Liver, 2012, 6, 2, 149

    CrossRef

  9. 9
    Valentina Volynets, Markus A. Küper, Stefan Strahl, Ina B. Maier, Astrid Spruss, Sabine Wagnerberger, Alfred Königsrainer, Stephan C. Bischoff, Ina Bergheim, Nutrition, Intestinal Permeability, and Blood Ethanol Levels Are Altered in Patients with Nonalcoholic Fatty Liver Disease (NAFLD), Digestive Diseases and Sciences, 2012,

    CrossRef

  10. 10
    T. Adar, A. Ben Ya'acov, G. Lalazar, Y. Lichtenstein, D. Nahman, M. Mizrahi, V. Wong, B. Muller, G. Rawlin, Y. Ilan, Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells, Clinical & Experimental Immunology, 2012, 167, 2
    Direct Link:
  11. 11
    Maud Lemoine, Lawrence Serfaty, Stéatopathies métaboliques, La Presse Médicale, 2012, 41, 2, 169

    CrossRef

  12. 12
    Adam P Levene, Robert D Goldin, The epidemiology, pathogenesis and histopathology of fatty liver disease, Histopathology, 2012, 60, 7
    Direct Link:
  13. 13
    Jill A. Parnell, Maitreyi Raman, Kevin P. Rioux, Raylene A. Reimer, The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance, Liver International, 2012, 32, 5
    Direct Link:
  14. 14
    Erwin Gäbele, Karin Dostert, Christoph Dorn, Eleonora Patsenker, Felix Stickel, Claus Hellerbrand, A New Model of Interactive Effects of Alcohol and High-Fat Diet on Hepatic Fibrosis, Alcoholism: Clinical and Experimental Research, 2011, 35, 7
    Direct Link:
  15. 15
    Guglielmo M. Trovato, Giuseppe Fabio Martines, Francesca M. Trovato, Clara Pirri, Patrizia Pace, Adriana Garozzo, Angelo Castro, Daniela Catalano, Adenovirus-36 Seropositivity Enhances Effects of Nutritional Intervention on Obesity, Bright Liver, and Insulin Resistance, Digestive Diseases and Sciences, 2011, 57, 2, 535

    CrossRef

  16. 16
    Kazushi Sugimoto, Yoshiyuki Takei, Clinicopathological features of non-alcoholic fatty liver disease, Hepatology Research, 2011, 41, 10
    Direct Link:
  17. 17
    Clett Erridge, Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease, Atherosclerosis, 2011, 216, 1, 1

    CrossRef

  18. 18
    Erwin Gäbele, Karin Dostert, Claudia Hofmann, Reiner Wiest, Jürgen Schölmerich, Claus Hellerbrand, Florian Obermeier, DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH, Journal of Hepatology, 2011, 55, 6, 1391

    CrossRef

  19. 19
    Pietro Vajro, Claudia Mandato, Maria Rosaria Licenziati, Adriana Franzese, Dino Franco Vitale, Selvaggia Lenta, Maria Caropreso, Gianfranco Vallone, Rosaria Meli, Effects of Lactobacillus rhamnosus Strain GG in Pediatric Obesity-related Liver Disease, Journal of Pediatric Gastroenterology and Nutrition, 2011, 52, 6, 740

    CrossRef

  20. 20
    Christopher L. Gentile, Melinda Frye, Michael J. Pagliassotti, Endoplasmic Reticulum Stress and the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease, Antioxidants & Redox Signaling, 2011, 15, 2, 505

    CrossRef

  21. 21
    Timea Csak, Michal Ganz, Justin Pespisa, Karen Kodys, Angela Dolganiuc, Gyongyi Szabo, Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells, Hepatology, 2011, 54, 1
    Direct Link:
  22. 22
    L. Serfaty, L. Castera, P. Marcellin, First European Young Hepatologist Workshop: topics and advances, Clinics and Research in Hepatology and Gastroenterology, 2011, 35, S1

    CrossRef

  23. 23
    Satu Korpimäki, Katri Kaukinen, Pekka Collin, Anna-Maija Haapala, Päivi Holm, Kaija Laurila, Kalle Kurppa, Päivi Saavalainen, Katri Haimila, Jukka Partanen, Markku Mäki, Marja-Leena Lähdeaho, Gluten-Sensitive Hypertransaminasemia in Celiac Disease: An Infrequent and Often Subclinical Finding, The American Journal of Gastroenterology, 2011, 106, 9, 1689

    CrossRef

  24. 24
    Davide Festi, Ramona Schiumerini, Chiara Birtolo, Luca Marzi, Lucia Montrone, Eleonora Scaioli, Anna Rita Di Biase, Antonio Colecchia, Gut Microbiota and Its Pathophysiology in Disease Paradigms, Digestive Diseases, 2011, 29, 6, 518

    CrossRef

  25. 25
    Claudia Cesaro, Angelo Tiso, Anna Del Prete, Rita Cariello, Concetta Tuccillo, Gaetano Cotticelli, Camillo del Vecchio Blanco, Carmelina Loguercio, Gut microbiota and probiotics in chronic liver diseases, Digestive and Liver Disease, 2011, 43, 6, 431

    CrossRef

  26. 26
    Kaushal K. Prasad, Uma Debi, Saroj K. Sinha, Chander K. Nain, Kartar Singh, Hepatobiliary Disorders in Celiac Disease: An Update, International Journal of Hepatology, 2011, 2011, 1

    CrossRef

  27. 27
    R Christopher Harmon, Dina G Tiniakos, Curtis K Argo, Inflammation in nonalcoholic steatohepatitis, Expert Review of Gastroenterology & Hepatology, 2011, 5, 2, 189

    CrossRef

  28. 28
    Giovanni Musso, Roberto Gambino, Maurizio Cassader, Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes, Annual Review of Medicine, 2011, 62, 1, 361

    CrossRef

  29. 29
    Anders Gummesson, Lena M.S. Carlsson, Len H. Storlien, Fredrik Bäckhed, Pål Lundin, Lars Löfgren, Kaj Stenlöf, Yan Y. Lam, Björn Fagerberg, Björn Carlsson, Intestinal Permeability Is Associated With Visceral Adiposity in Healthy Women, Obesity, 2011, 19, 11, 2280

    CrossRef

  30. 30
    Rodolphe Anty, Maud Lemoine, Liver fibrogenesis and metabolic factors, Clinics and Research in Hepatology and Gastroenterology, 2011, 35, S10

    CrossRef

  31. 31
    Venessa Pattullo, Mark W Douglas, Jacob George, Organelle dysfunction in hepatitis C virus-associated steatosis: anything to learn from nonalcoholic steatohepatitis?, Expert Review of Gastroenterology & Hepatology, 2011, 5, 2, 265

    CrossRef

  32. 32
    Astrid Spruss, Giridhar Kanuri, Kirsten Uebel, Stephan C. Bischoff, Ina Bergheim, Role of the Inducible Nitric Oxide Synthase in the Onset of Fructose-Induced Steatosis in Mice, Antioxidants & Redox Signaling, 2011, 14, 11, 2121

    CrossRef

  33. 33
    Keiichiro Sugimoto, Sayaka Sakamoto, Kazuya Nakagawa, Shuichi Hayashi, Naoki Harada, Ryoichi Yamaji, Yoshihisa Nakano, Hiroshi Inui, Suppression of inducible nitric oxide synthase expression and amelioration of lipopolysaccharide-induced liver injury by polyphenolic compounds in Eucalyptus globulus leaf extract, Food Chemistry, 2011, 125, 2, 442

    CrossRef

  34. 34
    G. Szabo, P. Mandrekar, J. Petrasek, D. Catalano, The Unfolding Web of Innate Immune Dysregulation in Alcoholic Liver Injury, Alcoholism: Clinical and Experimental Research, 2011, 35, 5
    Direct Link:
  35. 35
    Sabine Wagnerberger, Astrid Spruss, Giridhar Kanuri, Valentina Volynets, Carolin Stahl, Stephan C. Bischoff, Ina Bergheim, Toll-like receptors 1–9 are elevated in livers with fructose-induced hepatic steatosis, British Journal of Nutrition, 2011, 1

    CrossRef

  36. 36
    Sunil Kumar, Uday C. Ghoshal, Kamaiah Jayalakshmi, Raja Roy, Asha Misra, C. L. Khetrapal, Abnormal Small Intestinal Permeability in Patients with Idiopathic Malabsorption in Tropics (Tropical Sprue) Does Not Change Even After Successful Treatment, Digestive Diseases and Sciences, 2010, 56, 1, 161

    CrossRef

  37. 37
    Amedeo Lonardo, Stephen H Caldwell, Paola Loria, Clinical physiology of NAFLD: a critical overview of pathogenesis and treatment, Expert Review of Endocrinology & Metabolism, 2010, 5, 3, 403

    CrossRef

  38. 38
    Gakuhei Son, Michael Kremer, Ian N. Hines, Contribution of Gut Bacteria to Liver Pathobiology, Gastroenterology Research and Practice, 2010, 2010, 1

    CrossRef

  39. 39
    Angel Brea Hernando, José Puzo Foncillas, Enfermedad del hígado graso no alcohólico y riesgo cardiovascular, Clínica e Investigación en Arteriosclerosis, 2010, 22, 6, 259

    CrossRef

  40. 40
    Herbert Tilg, Alexander R. Moschen, Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis, Hepatology, 2010, 52, 5
    Direct Link:
  41. 41
    Giovanni Musso, Roberto Gambino, Maurizio Cassader, Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders, Current Opinion in Lipidology, 2010, 21, 1, 76

    CrossRef

  42. 42
    G. Musso, R. Gambino, M. Cassader, Non-alcoholic fatty liver disease from pathogenesis to management: an update, Obesity Reviews, 2010, 11, 6
    Direct Link:
  43. 43
    Marcin Krawczyk, Leonilde Bonfrate, Piero Portincasa, Nonalcoholic fatty liver disease, Best Practice & Research Clinical Gastroenterology, 2010, 24, 5, 695

    CrossRef

  44. 44
    Claus Hellerbrand, Pathophysiological Similarities and Synergisms in Alcoholic and Non-Alcoholic Steatohepatitis, Digestive Diseases, 2010, 28, 6, 783

    CrossRef

  45. 45
    Onpan Cheung, Arun J Sanyal, Recent advances in nonalcoholic fatty liver disease, Current Opinion in Gastroenterology, 2010, 26, 3, 202

    CrossRef

  46. 46
    Eamonn M.M. Quigley, Ahmed Abu-Shanab, Small Intestinal Bacterial Overgrowth, Infectious Disease Clinics of North America, 2010, 24, 4, 943

    CrossRef

  47. 47
    Ahmed Abu-Shanab, Eamonn M. M. Quigley, The role of the gut microbiota in nonalcoholic fatty liver disease, Nature Reviews Gastroenterology & Hepatology, 2010, 7, 12, 691

    CrossRef

  48. 48
    Kouichi Miura, Yuzo Kodama, Sayaka Inokuchi, Bernd Schnabl, Tomonori Aoyama, Hirohide Ohnishi, Jerrold M. Olefsky, David A. Brenner, Ekihiro Seki, Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice, Gastroenterology, 2010, 139, 1, 323

    CrossRef

  49. 49
    Kazuma Hamada, Yoshihisa Shitara, Shuichi Sekine, Toshiharu Horie, Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats, Cancer Chemotherapy and Pharmacology, 2010, 66, 6, 1031

    CrossRef

  50. 50
    Emidio Scarpellini, Venanzio Valenza, Maurizio Gabrielli, Ernesto Cristiano Lauritano, Germano Perotti, Giuseppe Merra, Antonio Dal Lago, Veronica Ojetti, Maria Elena Ainora, Michele Santoro, Giovanni Ghirlanda, Antonio Gasbarrini, Intestinal Permeability in Cirrhotic Patients With and Without Spontaneous Bacterial Peritonitis: Is the Ring Closed?, The American Journal of Gastroenterology, 2009, 105, 2, 323

    CrossRef

  51. 51
    J. K. Dowman, J.W. Tomlinson, P.N. Newsome, Pathogenesis of non-alcoholic fatty liver disease, QJM, 2009, 103, 2, 71

    CrossRef

  52. 52
    Ester Vanni, Elisabetta Bugianesi, The gut-liver axis in nonalcoholic fatty liver disease: Another pathway to insulin resistance?, Hepatology, 2009, 49, 6
    Direct Link:
  53. 53
    Stephen H. Caldwell, Curtis K. Argo, Non-Alcoholic Fatty Liver Disease and Nutrition,
    Direct Link:
  54. 54
    Stephen H. Caldwell, Curtis K. Argo, Abdullah M. S. Al-Osaimi, Nonalcoholic Fatty Liver Disease,
    Direct Link:
View Full Article (HTML) Get PDF (1034K)