Indirect action of tumor necrosis factor-alpha in liver injury during the CD8+ T cell response to an adeno-associated virus vector in mice†
Version of Record online: 2 FEB 2009
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 49, Issue 6, pages 2010–2020, June 2009
How to Cite
Giannandrea, M., Pierce, R. H. and Crispe, I. N. (2009), Indirect action of tumor necrosis factor-alpha in liver injury during the CD8+ T cell response to an adeno-associated virus vector in mice. Hepatology, 49: 2010–2020. doi: 10.1002/hep.22869
Potential conflict of interest: Nothing to report.
- Issue online: 28 MAY 2009
- Version of Record online: 2 FEB 2009
- Accepted manuscript online: 2 FEB 2009 12:00AM EST
- Manuscript Accepted: 24 JAN 2009
- Manuscript Received: 20 OCT 2008
- National Institutes of Health (NIH). Grant Numbers: R01AI064463, R01DK075274
- NIH Training Program in Viral Disease, Vaccines / Biodefense. Grant Number: T32 AI 007 169
Additional Supporting Information may be found in the online version of this article.
|HEP_22869_sm_SupFig1.tif||964K||Supporting Figure 1: GFP e×pression and liver injury are present throughout the liver. (A) C57BL6 mice were given an intrahepatic injection of the rAAV2 GFP vector and > 3 weeks later liver tissue was harvested and sections were stained for GFP. (B) C57BL6 mice were given the rAAV2 GFP-SIINFEKL vector plus 5×106 OT-1 cells appro×imately 3 weeks later. Day 3 post OT-1 transfer, harvested liver sections were stained for CD3.|
|HEP_22869_sm_SupFig2.tif||88K||Supporting Figure 2: TRAIL e×pression is not changed by loss of TNFR1 signaling. Three days post OT-1 cell transfer TNFR1 -/- (A), WT TNFR1 -/- chimeras (B) and their WT controls had liver mRNA measured for TRAIL e×pression. N.S. not significant. Data are representative, or the sum, of two independent e×periments.|
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