Additional Supporting Information may be found in the online version of this article.

HEP_22888_sm_SupplFig1.tif91KSupporting Fig. 1. The effect of synthetic CRP pretreatment on the phagocytotic activity of Kupffer cells after lethal E. coli infection in mice. CRP/PBS-pretreated mice (1 h before) were injected i.v. with FITC-microspheres 1 h after lethal E.coli injection. Liver MNCs were obtained from the mice 20 min after the microsphere injection to evaluate microsphere-phagocytosis by Kupffer cells. The data are representatives from three mice with similar results in each group.
HEP_22888_sm_SupplFig2.tif67KSupporting Fig. 2. The effect of synthetic CRP pretreatment on the generalized Shwartzman reaction. Mice were injected i.p. with IL-12 and, 16 h later, LPS was injected i.v.. They were pretreated with CRP (50, 250, or 500 μg) or PBS 1 h before LPS injection. The effect of CRP pretreatment on the survival rate (A) and the levels of serum TNF (B), and serum IFN-γ (C) after LPS challenge. Data are mean ± SE from ten mice in each group. * P<0.01, † P<0.05 vs. other groups.
HEP_22888_sm_SupplFig3.tif49KSupporting Fig. 3. The effect of synthetic CRP post-treatment on mouse survival after lethal E. coli challenge. Mice were challenged with the lethal dose of E. coli; after 1 h, they were injected i.v. with CRP/PBS. Survival rate are shown. N=10 in each group, *P<0.01.

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