See Editorial on Page 1795
Autoimmune, Cholestatic and Biliary Disease
Article first published online: 8 FEB 2009
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 49, Issue 6, pages 1972–1981, June 2009
How to Cite
Halilbasic, E., Fiorotto, R., Fickert, P., Marschall, H.-U., Moustafa, T., Spirli, C., Fuchsbichler, A., Gumhold, J., Silbert, D., Zatloukal, K., Langner, C., Maitra, U., Denk, H., Hofmann, A. F., Strazzabosco, M. and Trauner, M. (2009), Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2−/− mice. Hepatology, 49: 1972–1981. doi: 10.1002/hep.22891
Potential conflict of interest: Nothing to report.
The Medical University of Graz has filed the patent for the use of norUDCA in the treatment of liver diseases, and Michael Trauner, Alan Hofmann, and Peter Fickert are listed as inventors (publication number WO2006119803).
- Issue published online: 28 MAY 2009
- Article first published online: 8 FEB 2009
- Accepted manuscript online: 8 FEB 2009 12:00AM EST
- Manuscript Accepted: 26 JAN 2009
- Manuscript Received: 18 SEP 2008
- Austrian Science Foundation. Grant Number: P19118-B05
- GEN-AU project. Grant Number: GZ 200.139/1-VI/1/2006
- Austrian Ministry for Science
- Swedish Research Council
- The Swedish Medical Association
- Ph.D. program of the Medical University of Graz
- Fondazione S. Martino, Bergamo
- National Institutes of Health. Grant Numbers: DK079005, DK64891
- Yale University Liver Center (National Institutes of Health). Grant Number: DK34989
- Cystic Fibrosis Foundation. Grant Number: CFF-FIOROT0810
- ALF/AASLD Liver Scholar Award
- JNCASR, Bangalore
- 6Variation in the MDR3 gene influences disease progression in PSC patients and disease susceptibility in epistatic interaction with polymorphism in OST-alpha gene. HEPATOLOGY 2007; 46: 265A., , , , , , et al.
- 29Effect of side chain length on biotransformation, hepatic transport, and choleretic properties of chenodeoxycholyl homologues in the rodent: studies with dinorchenodeoxycholic acid, norchenodeoxycholic acid, and chenodeoxycholic acid. HEPATOLOGY 1997; 26: 374–385., , , , , , et al.