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Additional Supporting Information may be found in the online version of this article.

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HEP_22934_sm_SupFig1.TIF4226KSupplementary Figure 1. Smad2 phosphorylation in different types of liver cells. Immunofluorescence co-staining for phospho-Smad2 (green) and CD68/α-SMA (red) (markers for Kupffer cells (KC) and activated HSCs) was used to identify positivity of phospho-Smad2 in Kupffer cells and activated HSCs (top and medium panels). White frames and right panel highlighted co-location of phospho-Smad2 and CD68/α-SMA in liver tissue from a patient with chronic HBV infection. Immunohistochemical staining for phospho-Smad2 showed positivity of phospho-Smad2 in hepatocytes (blue arrow) and bile duct epithelial cells (black arrow) in the same patient.
HEP_22934_sm_SupFig2.TIF10244KSupplementary Figure 2. Representative pictures on phospho-Smad2 immunostaining in livers of patients with different CLDs, two specimens per CLD. Phospho-Smad2 positive nuclei (brown) are highlighted by arrows. Sj, S. japonicum.
HEP_22934_sm_SupFig3a.TIF4544KSupplementary Figure 3. IL-13 expression in different type of liver cells. (A) Immunohistochemical staining showing IL-13 positive staining in hepatocytes, sinusoidal cells and inflammatory cells in a representative patient with S. japonicum and HBV co-infection.
HEP_22934_sm_SupFig3b.TIF5946KSupplementary Figure 3. IL-13 expression in different type of liver cells. (B) In the same patient, immunofluorescence co-staining for IL-13 (red) and CK8/α-SMA/CD68 (green) highlighted IL-13 expression in hepatocytes, activated HSCs and Kupffer cells.
HEP_22934_sm_SupFig4.TIF11422KSupplementary Figure 4. Representative pictures on IL-13 immunostaining (brown) in livers specimens of patients with different CLDs, two per CLD. Sj, S. japonicum.
HEP_22934_sm_SupTab1.doc40KSupplementary Table 1. Characteristics of patients with different kinds of chronic liver disease
HEP_22934_sm_SupTab2.doc32KSupplementary Table 2. Characteristics of patients with chronic hepatitis C and healthy volunteers
HEP_22934_sm_SupTab3.doc41KSupplementary Table 3. phospho-Smad2 IHC score in liver tissues with different degree of inflammation/fibrosis
HEP_22934_sm_SupTab4.doc44KSupplementary Table 4. IL-13 IHC score in liver tissues with different degree of inflammation/fibrosis

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