Toll-like receptor 3 signaling attenuates liver regeneration†
Article first published online: 19 MAR 2009
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 50, Issue 1, pages 198–206, July 2009
How to Cite
Zorde-Khvalevsky, E., Abramovitch, R., Barash, H., Spivak-Pohis, I., Rivkin, L., Rachmilewitz, J., Galun, E. and Giladi, H. (2009), Toll-like receptor 3 signaling attenuates liver regeneration. Hepatology, 50: 198–206. doi: 10.1002/hep.22973
Potential conflict of interest: Nothing to report.
- Issue published online: 23 JUN 2009
- Article first published online: 19 MAR 2009
- Accepted manuscript online: 19 MAR 2009 12:00AM EST
- Manuscript Accepted: 7 MAR 2009
- Manuscript Received: 4 NOV 2008
- Israeli Science Foundation. Grant Numbers: LSHB-CT-2004-512034 (MOLEDA), LSHB-CT-2005-018961 (INTHER)
- Barbara Fox Miller support
- Judy Turetsky trust
- Wolfson Foundations
Additional Supporting Information may be found in the online version of this article.
|HEP_22973_sm_SupFig1.tif||195K||Supplementary Fig. 1S. The effect of anesthetics on ALT levels. TLR3wt and TLR3−/− mice were i.p. injected with the anesthetics Ketamine/Xylazine at the same conditions used in the PHx experiments (see Materials and Methods). At the noted time points blood was taken and ALT levels in the serum were measured. These data show that in young wt mice (2 and 3 months old) the anesthetics had only a mild effect on ALT serum levels. At the age of 6 months, the wt mice were more sensitive to the anesthetics. At this age, TLR3−/− mice were significantly less sensitive to the anesthetics than TLR3wt mice. Altogether, the entire effect of the anesthetics wore off at 6 hours post injection.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.