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Single nucleotide polymorphism–mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency†

  1. Shujuan Pan1,
  2. Lu Huang2,
  3. John McPherson4,
  4. Donna Muzny4,
  5. Farshid Rouhani5,
  6. Mark Brantly5,
  7. Richard Gibbs4,
  8. Richard N. Sifers1,2,3,4,‡,*

Article first published online: 19 MAR 2009

DOI: 10.1002/hep.22974

Issue

Hepatology

Hepatology

Volume 50, Issue 1, pages 275–281, July 2009

Additional Information

How to Cite

Pan, S., Huang, L., McPherson, J., Muzny, D., Rouhani, F., Brantly, M., Gibbs, R. and Sifers, R. N. (2009), Single nucleotide polymorphism–mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency. Hepatology, 50: 275–281. doi: 10.1002/hep.22974

Author Information

  1. 1

    Department of Pathology, Baylor College of Medicine, Houston, TX

  2. 2

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX

  3. 3

    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX

  4. 4

    Department of Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX

  5. 5

    Department of Medicine, University of Florida, Gainesville, FL

  1. ‡

    telephone: 713-798-3169

*Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM315, Houston, TX, 77030

  1. †

    Potential conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 23 JUN 2009
  2. Article first published online: 19 MAR 2009
  3. Accepted manuscript online: 19 MAR 2009 12:00AM EST
  4. Manuscript Accepted: 7 MAR 2009
  5. Manuscript Received: 22 AUG 2008

Funded by

  • NIH. Grant Number: DK064232
  • Fernandez Liver Initiative research grant FO3-12 from the Alpha-1 Foundation
  • Alpha-1 Foundation
  • Liver Tissue Cell Distribution System (LTCDS). Grant Number: #N01-DK-7-0004 / HHSN267200700004C
  • Alpha1-Foundation–University of Florida DNA and Tissue Bank

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