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The gut-liver axis in nonalcoholic fatty liver disease: Another pathway to insulin resistance?†‡
Article first published online: 22 APR 2009
DOI: 10.1002/hep.23036
Copyright © 2009 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Vanni, E. and Bugianesi, E. (2009), The gut-liver axis in nonalcoholic fatty liver disease: Another pathway to insulin resistance?. Hepatology, 49: 1790–1792. doi: 10.1002/hep.23036
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See Article on Page 1877
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Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 28 MAY 2009
- Article first published online: 22 APR 2009
- Accepted manuscript online: 22 APR 2009 12:00AM EST
References
- 1, , , , , . Gut microbiota and its possible relationship with obesity. Mayo Clin Proc 2008; 83: 460–469.
- 2, . Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics. J Hepatol 2003; 38: 681–687.
- 3, , , , , , et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007; 292: G518–G525.
- 4, , , , , . The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis. Gut 2001; 48: 206–211.
- 5, , , , , . Ciprofloxacin suppresses bacterial overgrowth, increases fasting insulin but does not correct low acylated ghrelin concentration in non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2005; 22: 291–299.Direct Link:
- 6, , , , , , et al. High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosis. Obes Surg 2008; 18: 371.
- 7, , , , , , et al. Increased intestinal permeability and tight junction alterations in non-alcoholic fatty liver disease (NAFLD). HEPATOLOGY 2009; doi:10.1002/hep.22848.Direct Link:
- 8, , , , . Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci U S A 1997; 94: 2557–2562.
- 9, , , , , , et al. Eradication of small intestinal bacterial overgrowth and oro-cecal transit in diabetics. Hepatogastroenterology 2002; 49: 1582–1586.
- 10, , , , , , et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004; 101: 15718–15723.
- 11, , , , , . Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 2005; 102: 11070–11075.
- 12, , , , , . An obesity-associated gut microbiome with increased capacity fro energy harvest. Nature 2006; 444: 1027–1031.
- 13, , , . Human gut microbes associated with obesity. Nature 2006; 444: 1022–1023.
- 14, , , , , , et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007; 56: 1761–1772.
- 15, , , , , , et al. Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J Hepatol 2008; 48: 983–992.
- 16, , , , , , et al. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr 2008; 87: 1219–1223.
- 17, . Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: a case for dimensionality reduction? Mutat Res 2007; 622: 19–32.
- 18, , , , , . TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006; 116: 3015–3026.
- 19, , , , , , et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008; 57: 1470–1481.
- 20, , , , , , et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007; 50: 2374–2383.
- 21, , , , , , et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. HEPATOLOGY 2003; 37: 343–350.Direct Link:
- 22, , , , , , et al. Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. FASEB J 2008; 22: 2416–2426.

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