Article first published online: 13 JUL 2009
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 50, Issue 5, pages 1360–1369, November 2009
How to Cite
Freedman, N. D., Everhart, J. E., Lindsay, K. L., Ghany, M. G., Curto, T. M., Shiffman, M. L., Lee, W. M., Lok, A. S., Di Bisceglie, A. M., Bonkovsky, H. L., Hoefs, J. C., Dienstag, J. L., Morishima, C., Abnet, C. C., Sinha, R. and HALT-C Trial Group (2009), Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C. Hepatology, 50: 1360–1369. doi: 10.1002/hep.23162
This is publication #38 from the HALT-C Trial Group.
Financial relationships of the authors with Hoffmann-La Roche, Inc., are as follows: K.L.L. is a consultant and receives research support; M.L.S. is a consultant, on the speaker's bureau, and receives research support; W.M.L. receives research support; A.S.L. is a consultant; A.M.D. is a consultant, on the speaker's bureau, and receives research support; H.L.B. receives research support; J.C.H. is on the speaker's bureau. Authors with no financial relationships related to this project are: N.D.F., J.E.E., M.G.G., T.M.C., C.C.A., R.S., J.L.D., and C.M.
The funding organizations had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
The HALT-C Trial was registered with clinicaltrials.gov (#NCT00006164).
- Issue published online: 29 OCT 2009
- Article first published online: 13 JUL 2009
- Accepted manuscript online: 13 JUL 2009 12:00AM EST
- Manuscript Accepted: 2 JUL 2009
- Manuscript Received: 17 MAR 2009
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Allergy and Infectious Diseases
- National Cancer Institute
- National Center for Minority Health and Health Disparities and by General Clinical Research Center
- National Center for Research Resources
- National Institutes of Health
- Intramural Research Program of the National Cancer Institute
- Hoffmann-La Roche, Inc. through a Cooperative Research and Development Agreement with the National Institutes of Health
Higher coffee consumption has been associated inversely with the incidence of chronic liver disease in population studies. We examined the relationship of coffee consumption with liver disease progression in individuals with advanced hepatitis C–related liver disease. Baseline coffee and tea intake were assessed in 766 participants of the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis (HALT-C) trial who had hepatitis C–related bridging fibrosis or cirrhosis on liver biopsy and failed to achieve a sustained virological response to peginterferon plus ribavirin treatment. Participants were followed for 3.8 years for clinical outcomes and, for those without cirrhosis, a 2-point increase in Ishak fibrosis score on protocol biopsies. At baseline, higher coffee consumption was associated with less severe steatosis on biopsy, lower serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio, alpha-fetoprotein, insulin, and homeostatic model assessment (HOMA2) score, and higher albumin (P < 0.05 for all). Two hundred thirty patients had outcomes. Outcome rates declined with increasing coffee intake: 11.1/100 person-years for none, 12.1 for less than 1 cup/day, 8.2 for 1 to fewer than 3 cups/day, and 6.3 for 3 or more cups/day (P-trend = 0.0011). Relative risks (95% confidence intervals) were 1.11 (0.76-1.61) for less than 1 cup/day; 0.70 (0.48-1.02) for 1 to fewer than 3 cups/day; and 0.47 (0.27-0.85) for 3 or more cups/day (P-trend = 0.0003) versus not drinking. Risk estimates did not vary by treatment assignment or cirrhosis status at baseline. Tea intake was not associated with outcomes. Conclusion: In a large prospective study of participants with advanced hepatitis C–related liver disease, regular coffee consumption was associated with lower rates of disease progression. (HEPATOLOGY 2009.)