1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8 "Hepatology")
fax: 301-496-6829
1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
Viral Hepatitis
You have free access to this content
Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C†‡§
Article first published online: 13 JUL 2009
DOI: 10.1002/hep.23162
Copyright © 2009 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Freedman, N. D., Everhart, J. E., Lindsay, K. L., Ghany, M. G., Curto, T. M., Shiffman, M. L., Lee, W. M., Lok, A. S., Di Bisceglie, A. M., Bonkovsky, H. L., Hoefs, J. C., Dienstag, J. L., Morishima, C., Abnet, C. C., Sinha, R. and HALT-C Trial Group (2009), Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C. Hepatology, 50: 1360–1369. doi: 10.1002/hep.23162
- †
This is publication #38 from the HALT-C Trial Group.
- ‡
Financial relationships of the authors with Hoffmann-La Roche, Inc., are as follows: K.L.L. is a consultant and receives research support; M.L.S. is a consultant, on the speaker's bureau, and receives research support; W.M.L. receives research support; A.S.L. is a consultant; A.M.D. is a consultant, on the speaker's bureau, and receives research support; H.L.B. receives research support; J.C.H. is on the speaker's bureau. Authors with no financial relationships related to this project are: N.D.F., J.E.E., M.G.G., T.M.C., C.C.A., R.S., J.L.D., and C.M.
- §
The funding organizations had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Publication History
- Issue published online: 29 OCT 2009
- Article first published online: 13 JUL 2009
- Accepted manuscript online: 13 JUL 2009 12:00AM EST
- Manuscript Accepted: 2 JUL 2009
- Manuscript Received: 17 MAR 2009
Funded by
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Allergy and Infectious Diseases
- National Cancer Institute
- National Center for Minority Health and Health Disparities and by General Clinical Research Center
- National Center for Research Resources
- National Institutes of Health
- Intramural Research Program of the National Cancer Institute
- Hoffmann-La Roche, Inc. through a Cooperative Research and Development Agreement with the National Institutes of Health
References
- 1. Global challenges in liver disease. HEPATOLOGY 2006; 44: 521–526.Direct Link:
- 2, , , , , , et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975–982.
- 3, , , . The Tromso Heart Study: distribution of, and determinants for, gamma-glutamyltransferase in a free-living population. Scand J Clin Lab Invest 1986; 46: 63–70.
- 4, , , . Unexpected effects of coffee consumption on liver enzymes. Eur J Epidemiol 1993; 9: 293–297.
- 5, , , , , , et al. Coffee consumption and serum aminotransferases in middle-aged Japanese men. J Clin Epidemiol 2001; 54: 823–829.
- 6, , , . Coffee, cirrhosis, and transaminase enzymes. Arch Intern Med 2006; 166: 1190–1195.
- 7, . Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2005; 128: 24–32.
- 8, , , , , , et al. Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers. Int J Epidemiol 1998; 27: 438–443.
- 9, , , , . Coffee, caffeine, and the risk of liver cirrhosis. Ann Epidemiol 2001; 11: 458–465.
- 10, , , . Does coffee protect against liver cirrhosis? Ann Epidemiol 2002; 12: 202–205.
- 11
- 12, . Coffee intake and mortality from liver cirrhosis. Ann Epidemiol 2003; 13: 419–423.
- 13, . Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States. Gastroenterology 2005; 129: 1928–1936.
- 14, . Coffee consumption and risk of liver cancer: a meta-analysis. Gastroenterology 2007; 132: 1740–1745.
- 15, , , , , , et al. Coffee drinking and hepatocellular carcinoma risk: a meta-analysis. HEPATOLOGY 2007; 46: 430–435.Direct Link:
- 16, , , . Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species. Biochim Biophys Acta 1996; 1282: 63–70.
- 17, , , , , . Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. J Hepatol 2008; 49: 758–767.
- 18, , . In vitro antioxidant activity of coffee compounds and their metabolites. J Agric Food Chem 2007; 55: 6962–6969.
- 19. Antioxidant ability of caffeine and its metabolites based on the study of oxygen radical absorbing capacity and inhibition of LDL peroxidation. Clin Chim Acta 2000; 295: 141–154.
- 20, , , , , . Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food Chem Toxicol 2002; 40: 1155–1163.
- 21, . Coffee and tea consumption and chronic liver disease. Gastroenterology 2006; 130: 1931–1932.
- 22, , , , , , et al. Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon. N Engl J Med 2008; 359: 2429–2441.
- 23, , , , , , et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696–699.
- 24, , . Use and abuse of HOMA modeling. Diabetes Care 2004; 27: 1487–1495.
- 25, , , . Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol 1990; 43: 1327–1335.
- 26, , , , . Comparison of two dietary questionnaires validated against multiple dietary records collected during a 1-year period. J Am Diet Assoc 1992; 92: 686–693.
- 27, . The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992; 30: 473–483.
- 28. Regression models and life-tables. J R Stat Soc Series B Stat Methodol 1972; 34: 187.
- 29, . Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA 2005; 294: 97–104.
- 30, . Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003; 124: 71–79.
- 31, , , , , , et al. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch Biochem Biophys 1997; 339: 315–322.
- 32
- 33. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008; 134: 1655–1669.
- 34, , , . Consumption of coffee is associated with reduced risk of death attributed to inflammatory and cardiovascular diseases in the Iowa Women's Health Study. Am J Clin Nutr 2006; 83: 1039–1046.
- 35, , , , . The relationship of coffee consumption with mortality. Ann Intern Med 2008; 148: 904–914.
- 36, , , . Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Am J Clin Nutr 2006; 84: 888–893.
- 37, , , , . Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study. Am J Clin Nutr 2004; 80: 862–867.
- 38, . Steatohepatitis: a tale of two “hits”? Gastroenterology 1998; 114: 842–845.
- 39, , , , , , et al. Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene. Food Chem Toxicol 2001; 39: 557–561.
- 40, , . Black tea consumption and cancer risk: a prospective study. Br J Cancer 1986; 54: 677–683.
- 41, , , . Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan. J Natl Cancer Inst 2005; 97: 293–300.
- 42, , , , , , et al. Coffee and tea consumption and risk of hepatocellular carcinoma in Italy. Int J Cancer 2007; 120: 1555–1559.Direct Link: