Liver Injury/Regeneration

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Variability in the upper limit of normal for serum alanine aminotransferase levels: A statewide study†

  1. Anand Dutta1,
  2. Chandan Saha2,
  3. Cynthia S. Johnson2,
  4. Naga Chalasani1,3,‡,*

Article first published online: 5 AUG 2009

DOI: 10.1002/hep.23200

Issue

Hepatology

Hepatology

Volume 50, Issue 6, pages 1957–1962, December 2009

Additional Information

How to Cite

Dutta, A., Saha, C., Johnson, C. S. and Chalasani, N. (2009), Variability in the upper limit of normal for serum alanine aminotransferase levels: A statewide study. Hepatology, 50: 1957–1962. doi: 10.1002/hep.23200

Author Information

  1. 1

    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN

  2. 2

    Division of Biostatistics,Department of Medicine, Indiana University School of Medicine, Indianapolis, IN

  3. 3

    Clarian/Indiana University Digestive Disease Center, Indianapolis, IN

  1. ‡

    fax 317-278-1949.

*Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4100, Indianapolis, IN 46202

  1. †

    Potential conflict of interest: Nothing to report.

  2. ‡

    fax 317-278-1949.

Publication History

  1. Issue published online: 20 NOV 2009
  2. Article first published online: 5 AUG 2009
  3. Accepted manuscript online: 5 AUG 2009 12:00AM EST
  4. Manuscript Accepted: 22 JUL 2009
  5. Manuscript Received: 12 FEB 2009

Funded by

  • Public Health Service grant. Grant Number: K24DK069290

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References

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    Kim H, Nam C, Jee S, Han K, Oh D, Suh I. Normal serum aminotransferase concentration and risk of mortality from liver disease: prospective cohort study. BMJ 2004; 328: 983
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    Kim WR, Benson JT, Therneau TM, Buritt MF, Melton LJ. Serum aminotransferase activity and risk of mortality in a U. S. community population. HEPATOLOGY 2008; 47; 880–887.
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    Ioannou G, Weiss N, Boyko E, Mozaffarian D. Elevated serum alanine aminotransferase activity and calculated risk of coronary artery disease in the United States. HEPATOLOGY 2006; 43: 1145–1151.
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    Kim WR, Flamm SL, Di Bisceglie AM, Bodenheimer HC; Public Policy Committee of the American Association for the Study of Liver Disease. Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. HEPATOLOGY 2008; 47: 1363–1373.
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    Horowitz GL, Altaie A, Boyd JC, Ceriotto F, Garg U, Horn P, et al. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline—Third Edition. Clinical and Laboratory Standards Institute C28–A3, volume 28(30), 2008.
  • 7
    Neuschwander-Tetri BA, Unalp A, Creer MH, Nonalcoholic steatohepatitis Clinical Research Network. Influence of local reference populations on upper limits of normal for serum alanine aminotransferase levels. Arch Intern Med 2008; 24: 663–666.
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