fax: 617-643-0446.
Viral Hepatitis
You have full text access to this OnlineOpen article
Hepatitis C virus infection and its clearance alter circulating lipids: Implications for long-term follow-up†
Article first published online: 10 AUG 2009
DOI: 10.1002/hep.23219
Copyright © 2009 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Corey, K. E., Kane, E., Munroe, C., Barlow, L. L., Zheng, H. and Chung, R. T. (2009), Hepatitis C virus infection and its clearance alter circulating lipids: Implications for long-term follow-up. Hepatology, 50: 1030–1037. doi: 10.1002/hep.23219
- †
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 28 SEP 2009
- Article first published online: 10 AUG 2009
- Accepted manuscript online: 10 AUG 2009 12:00AM EST
- Manuscript Accepted: 27 APR 2009
- Manuscript Received: 10 FEB 2009
Funded by
- Bristol-Myer-Squibb Virology Fellowship
- Roche Laboratories
- Schering-Plough
References
- 1, , , , , . The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med 2006; 144: 705–714.
- 2, , , , , , et al. Preferential association of Hepatitis C virus with apolipoprotein B48-containing lipoproteins. J Gen Virol 2006; 87: 2983–2991.
- 3, , , , , , et al. Characterization of low- and very-low-density hepatitis C virus RNA-containing particles. J Virol 2002; 76: 6919–6928.
- 4, , , , . Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci U S A 1999; 96: 12766–12771.
- 5, , , , , , et al. The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus. J Hepatol 2007; 46: 411–419.
- 6, , . Interaction of hepatitis C virus proteins with host cell membranes and lipids. Trends Cell Biol 2002; 12: 517–523.
- 7, , , , , Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proc Natl Acad Sci U S A 2003; 100: 15865–15870.
- 8, , , , , , et al. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Mol Cell 2005; 18: 425–434.
- 9, , , , , , et al. Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin. HEPATOLOGY 2008; 47: 1437–1445.
- 10, , , , , , et al. Serum cholesterol and chronic hepatitis C. Ital J Gastroenterol 1996; 28: 436–440.
- 11, , , , , , et al. Metabolic and cardiovascular risk profiles and hepatitis C virus infection in rural Egypt. Gut 2007; 56: 1105–1110.
- 12, , , . Incidence of hyperlipidemia in chronic hepatitis C and response to anti-viral therapy in combination with HMG-CoA reductase inhibitors [Abstract M1779]. Presented at: Digestive Disease Week 2007; May 19-24; Washington, DC.
- 13National Heart, Lung and Blood Institute. Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Bethesda, MD: National Institutes of Health; 2004.
- 14, , . Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA 1986; 256: 2823–2828.
- 15, , , , . Blood lipids of patients with chronic hepatitis: differences related to viral etiology. Clin Chim Acta 1997; 261: 159–165.
- 16, , , , , . Hepatitis C infection is associated with lower lipids and high-sensitivity C-reactive protein in HIV-infected men. AIDS Patient Care STDS 2007; 21: 479–491.
- 17, , , , , , et al. Correlation between beta-lipoprotein levels and outcome of hepatitis C treatment. HEPATOLOGY 2006; 44: 335–340.
- 18, , , , , . Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis. Arch Intern Med 1997; 157: 792–796.
- 19, , , , , , et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 1995; 333: 1301–1307.
- 20, , , , , , et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 1998; 279: 1615–1622.
- 21Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383–1389.
- 22, , , . Weight loss during pegylated interferon and ribavirin treatment of chronic hepatitis C*. J Viral Hepat 2005; 12: 531–535.
- 23, , , , , , et al. Changes in blood lipid composition and response to interferon treatment in chronic hepatitis C. J Interferon Cytokine Res 1995; 15: 705–712.
- 24, . A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232: 34–47.

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8)