These authors contribute equally to this study.
Hepatobiliary Malignancies
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Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma†
Article first published online: 10 AUG 2009
DOI: 10.1002/hep.23221
Copyright © 2009 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Yang, M.-H., Chen, C.-L., Chau, G.-Y., Chiou, S.-H., Su, C.-W., Chou, T.-Y., Peng, W.-L. and Wu, J.-C. (2009), Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology, 50: 1464–1474. doi: 10.1002/hep.23221
- †
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 29 OCT 2009
- Article first published online: 10 AUG 2009
- Accepted manuscript online: 10 AUG 2009 12:00AM EST
- Manuscript Accepted: 9 JUL 2009
- Manuscript Received: 30 MAR 2009
Funded by
- National Science Council. Grant Numbers: NSC93-2321-B-010-012, 94-2321-B-010-010, 95-2321-B-010-005, 98-3112-B-010-017
- Ministry of Education, Aim for the Top University Plan. Grant Numbers: 96A-D-T304, 97A-C-T501
- Taipei Veterans General Hospital. Grant Numbers: V97ER2-016, V98ER2-017
- Fu-Jen Catholic University, Taipei, Taiwan. Grant Numbers: 109531030990-3, 109631030990-3
References
- 1Department of Health, the Executive Yuan, R.O.C. Cancer Registry Annual Report in Taiwan area, 2007.
- 2, , , , , , et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002; 347: 168–174.
- 3, , , , , , et al. The model for end-stage liver disease-based Japan Integrated Scoring system may have a better predictive ability for patients with hepatocellular carcinoma undergoing locoregional therapy. Cancer 2006; 107: 141–148.
- 4. Epithelial-mesenchymal transition in tumor progression. Nature Rev Cancer 2002; 2: 442–454.
- 5, . Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008; 14: 818–829.
- 6, , , , , , et al. A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 2006; 8: 1398–1406
- 7, , , , , , et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2: 76–83.
- 8, , , , , . The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003; 116(Pt 3): 499–511.
- 9, , , , , , et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004; 117: 927–939.
- 10, . TWIST activation by hypoxia inducible factor-1 (HIF-1): implication in metastasis and development. Cell Cycle 2008; 7: 2090–2096.
- 11, , , . Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers. Front Biosci 2009; 14: 3035–50.
- 12, , , , , , et al. Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res 2006; 12: 5369–5376.
- 13, , , , , , et al. Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma. Br J Cancer 2005; 92: 252–258.
- 14, , , , , , et al. Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer 2004; 90: 1265–1273.
- 15, , , , , , et al. Transcriptional repressor snail and progression of human hepatocellular carcinoma. Clin Cancer Res 2003; 9: 2657–2664.
- 16, , , , , , et al. Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Oncogene 2007; 26: 1459–1467.
- 17, , , , , , et al. Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol 1993; 142: 983–987.
- 18, , , , , . Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma. Mod Pathol 2006; 19: 533–540.
- 19, , , , , , et al. Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. J Hepatol 2009; 50: 948–957.
- 20, , , , , , et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008; 10: 295–305.
- 21, , , , . Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer. Clin Cancer Res 2003; 9: 295–306.
- 22, . TGF-beta and epithelial-to-mesenchymal transitions. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005; 24: 5764–5774.
- 23, , , , . Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 2005; 129: 1375–1383.
- 24, , , . Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. HEPATOLOGY 2008; 47: 1557–1566.
- 25, , , , , , et al. Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition. PLoS ONE 2009; 4: e4355.
- 26, , , , , , et al. Comparison of recurrence after hepatic resection in patients with hepatitis B vs. hepatitis C-related small hepatocellular carcinoma in hepatitis B endemic area. Liver Int 2005; 25: 236–241.
- 27, , , , , . N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1. Cancer Res 2006; 66: 3365–3369.
- 28, , , , , . Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res 2007; 67: 1979–1987.
- 29, , , , , , et al. Twist promotes tumor cell growth through YB-1 expression. Cancer Res 2008; 68: 98–105.
- 30, , , , , , et al. Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res 2005; 65: 10801–10809.

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