• 1
    Ballatori N, Fang F, Christian WV, Li N, Hammond CL. Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol 2008; 295: G179G186.
  • 2
    Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA. The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci U S A 2008; 105: 38913896.
  • 3
    Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, et al. OSTα-OSTβ: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. HEPATOLOGY 2005; 42: 12701279.
  • 4
    Dawson PA, Hubbert HJ, Craddock AL, Zeranque N, Christian WV, Ballatori N. The heteromeric organic solute transporter alpha-beta, Ostα-Ostβ, is an ileal basolateral bile acid transporter. J Biol Chem 2005; 280: 69606968.
  • 5
    Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2: 217225.
  • 6
    Seward DJ, Koh AS, Boyer JL, Ballatori N. Functional Complementation between a Novel Mammalian Polygenic Transport Complex and an Evolutionarily Ancient Organic Solute Transporter, OSTα-OSTβ. J Biol Chem 2003; 278: 2747327482.
  • 7
    Wang W, Seward DJ, Li L, Boyer JL, Ballatori N. Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate. Proc Natl Acad Sci U S A 2001; 98: 94319436.
  • 8
    Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai S-Y, Mounstafa T, et al. Upregulation of a basolateral RXR-dependent bile acid efflux transporter OSTα-OSTβ in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1124G1130.
  • 9
    Zollner G, Wagner M, Mounstafa T, Ficket P, Silbert D, Gumhold J, et al. Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-α/β in the adaptive response to bile acids. Am J Physiol Gastrointest Liver Physiol 2006; 290: G923G932.
  • 10
    Boyer JL. New perspectives for the treatment of cholestasis: lessons from basic science applied clinically. J Hepatol 2007; 46: 365371.
  • 11
    Kosters A, Karpen SJ. Bile acid transporters in health and disease. Xenobiotica 2008; 38: 10431071.
  • 12
    Belinsky MG, Dawson PA, Shchaveleva I, Bain LJ, Wang R, Ling V, et al. Analysis of the in vivo functions of Mrp3. Mol Pharmacol 2005; 68: 160168.
  • 13
    Zelcer N, van de Wetering K, de Waart R, Scheffer GL, Marschall H-U, Wielinga PR, et al. Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol 2006; 44: 768775.
  • 14
    Mennone A, Soroka CJ, Cai S-Y, Harry K, Adachi M, Hagey L, et al. Mrp4 -/- mice have an impaired cytoprotective response in obstructive cholestasis. HEPATOLOGY 2006; 43: 10131021.
  • 15
    Li N, Cui Z, Fang F, Lee JY, Ballatori N. Heterodimerization, trafficking and membrane topology of the two proteins, Ostα and Ostβ, that constiture the organic solute and steroid transporter. Biochem J 2007; 407: 363372.
  • 16
    Gartung C, Ananthanarayanan M, Rahman M, Schuele S, Nundy S, Soroka CJ, et al. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996; 110: 199209.
  • 17
    Trauner M, Arrese M, Soroka CJ, Ananthanarayannan M, Koeppel T, Schlosser S, et al. The rat canalicular conjugate export pump (mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997; 113: 255264.
  • 18
    Fickert P, Fuchsbichler A, Marschall H-U, Wagner M, Zollner G, Krause R, et al. Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice. Am J Pathol 2006; 168: 410422.
  • 19
    Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 2004; 126: 322342.
  • 20
    Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, et al. Mrp4 confers resistance to topotecan and protects the brain from chemotherapy. Mol Cell Biol 2004; 24: 76127621.
  • 21
    Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB Jr, Kliewer SA, et al. Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem 2003; 278: 4506245071.
  • 22
    Stedman CAM, Liddle C, Coulter SA, Sonoda J, Alvarez JGA, Moore DD, et al. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci U S A 2005; 102: 20632068.
  • 23
    Saini SPS, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, et al. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol 2004; 65: 292300.
  • 24
    Wagner M, Halilbasic E, Marschall H-U, Zollner G, Fickert P, Langner C, et al. CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. HEPATOLOGY 2005; 42: 420430.
  • 25
    Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, et al. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem 2004; 279: 2225022257.