Autoimmune, Cholestatic and Biliary Disease
Mouse organic solute transporter α deficiency enhances renal excretion of bile acids and attenuates cholestasis†
Article first published online: 4 SEP 2009
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 51, Issue 1, pages 181–190, January 2010
How to Cite
Soroka, C. J., Mennone, A., Hagey, L. R., Ballatori, N. and Boyer, J. L. (2010), Mouse organic solute transporter α deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology, 51: 181–190. doi: 10.1002/hep.23265
Potential conflict of interest: Nothing to report.
- Issue published online: 23 DEC 2009
- Article first published online: 4 SEP 2009
- Accepted manuscript online: 4 SEP 2009 12:00AM EST
- Manuscript Accepted: 25 AUG 2009
- Manuscript Received: 15 MAY 2009
- National Institutes of Health research. Grant Numbers: DK 25636, DK34989, DK067214
Additional Supporting Information may be found in the online version of this article.
|HEP_23265_sm_SuppFig1.tif||10451K||Supporting Fig. 1. Histology of liver tissue from Ostα+/+ and Ostα−/− mice. Hematoxylin and eosin staining demonstrates that livers from both Ostα+/+ and Ostα−/− BDL mice had increased numbers of infarcts, although blinded analysis did not find a significant difference between the groups.|
|HEP_23265_sm_SuppFig2.tif||357K||Supporting Fig. 2. Hepatic bile flow rates, and biliary excretion of total bile acids, cholesterol, and phospholipids in Ostα+/+ and Ostα−/− mice. Bile samples were collected from the common bile duct at 30 minutes intervals for 90 minutes in 5 male Ostα+/+ and 4 male Ostα−/− untreated mice that had been fed ad libitum. These animals had not undergone any prior treatment or surgical manipulations. Bile volumes were determined gravimetrically, assuming a density of 1.0, and bile flow is expressed as μl/min.g liver. Biliary total bile acids, cholesterol, and phospholipids are expressed both as excretion rates per gram of liver (panel B, D, and F, respectively), and as concentrations (panel C, E, and G, respectively). Values are means ± SD. *Significantly different from Ostα+/+ mice, P < 0.05.|
|HEP_23265_sm_SuppTab.doc||22K||Table S1: Antibodies used in this study|
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