These authors contributed equally to the study.
Liver Failure/Cirrhosis/Portal Hypertension
You have full text access to this OnlineOpen article
Increased caffeine consumption is associated with reduced hepatic fibrosis†
Article first published online: 9 SEP 2009
DOI: 10.1002/hep.23279
Copyright © 2009 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Modi, A. A., Feld, J. J., Park, Y., Kleiner, D. E., Everhart, J. E., Liang, T. J. and Hoofnagle, J. H. (2010), Increased caffeine consumption is associated with reduced hepatic fibrosis. Hepatology, 51: 201–209. doi: 10.1002/hep.23279
- †
Potential conflict of interest: Nothing to report.
Publication History
- Issue published online: 23 DEC 2009
- Article first published online: 9 SEP 2009
- Accepted manuscript online: 9 SEP 2009 12:00AM EST
- Manuscript Accepted: 21 AUG 2009
- Manuscript Received: 24 APR 2009
References
- 1, , , , . The relationship of coffee consumption with mortality. Ann Intern Med 2008; 148: 904–914.
- 2, . Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2005; 128: 24–32.
- 3, . Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States. Gastroenterology 2005; 129: 1928–1936.
- 4, , , . Coffee, cirrhosis, and transaminase enzymes. Arch Intern Med 2006; 166: 1190–1195.
- 5, , , , , , et al. Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers. Int J Epidemiol 1998; 27: 438–443.
- 6, , , . Unexpected effects of coffee consumption on liver enzymes. Eur J Epidemiol 1993; 9: 293–297.
- 7, , , , . Coffee and serum gamma-glutamyltransferase: a study of self-defense officials in Japan. Am J Epidemiol 1994; 139: 723–727.
- 8, , , , , , http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Umeda%20T%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPluset al. Coffee drinking and serum gamma-glutamyltransferase: an extended study of Self-Defense Officials of Japan. Ann Epidemiol 1999;9:325–331.
- 9, , , , , , http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Umeda%20T%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus et al. Coffee consumption and serum aminotransferases in middle-aged Japanese men. J Clin Epidemiol 2001;54:823–829.
- 10, , , , . Coffee, caffeine, and the risk of liver cirrhosis. Ann Epidemiol 2001; 11: 458–465.
- 11, . Coffee intake and mortality from liver cirrhosis. Ann Epidemiol 2003; 13: 419–423.
- 12, , , , , , et al. Coffee consumption reduces the risk of hepatocellular carcinoma independently of its aetiology: a case-control study. J Hepatol 2005; 42: 528–534.
- 13, , , . Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan. J Natl Cancer Inst 2005; 97: 293–300.
- 14, , , , , , et al. Coffee consumption and the risk of primary liver cancer: pooled analysis of two prospective studies in Japan. Int J Cancer 2005; 116: 150–154.
- 15, , , , , , et al. Does coffee protect against hepatocellular carcinoma? Br J Cancer 2002; 87: 956–959.
- 16, , , , , , http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Franceschi%20S%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPluset al. Coffee drinking and hepatocellular carcinoma risk: a meta-analysis. HEPATOLOGY 2007;46:430–435.
- 17, . Coffee consumption and risk of liver cancer: a meta-analysis. Gastroenterology 2007; 132: 1740–1745.
- 18, , , , , , et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696–699.
- 19, , , . Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer. J Natl Cancer Inst 2005; 97: 282–292.
- 20, , , , . The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med 2006; 144: 554–562.
- 21National Toxicology Program. Caffeine. Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.
- 22, , , , , , http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Takano%20T%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPluset al. Green tea consumption in everyday life and mental health. Public Health Nutr 2005;8:1300–1306.
- 23, . Caffeine consumption. Food Chem Toxicol 1996; 34: 119–129.
- 24, . Introduction to measurement theory: Long Grove, IL: Waveland Press; 2002.
- 25, , , , . Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2: evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. Toxicol Appl Pharmacol 2008; 226: 328–337.
- 26, , , , , , et al. Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. Food Chem Toxicol 2008; 46: 1230–1238.
- 27, , , , , , http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Piguet%20D%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPluset al. Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver. Food Chem Toxicol 2008;46:1239–1248.
- 28, , , , , , http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Meinl%20W%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPluset al. Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2). Food Chem Toxicol 2005;43:433–441.
- 29, , . Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol 2007; 45: 2118–2125.
- 30, , , , , . Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. J Hepatol 2008; 49: 758–767.

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8)