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Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A†
Article first published online: 9 SEP 2009
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 50, Issue 5, pages 1638–1645, November 2009
How to Cite
Ciesek, S., Steinmann, E., Wedemeyer, H., Manns, M. P., Neyts, J., Tautz, N., Madan, V., Bartenschlager, R., von Hahn, T. and Pietschmann, T. (2009), Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology, 50: 1638–1645. doi: 10.1002/hep.23281
Potential conflicts of interest: Dr. Ciesek received grants from Novartis. Dr. Wedemeyer advises, is on the speakers' bureau, and grants Novartis. Dr. Manns is a consultant, advises, is on the speakers' bureau of, and received grants from Novartis. He also received grants from Debio.
- Issue published online: 29 OCT 2009
- Article first published online: 9 SEP 2009
- Accepted manuscript online: 9 SEP 2009 12:00AM EST
- Manuscript Accepted: 24 AUG 2009
- Manuscript Received: 15 JUN 2009
- IFB-TX, a program of MHH funded by the Deutsche Forschungs-gemeinschaft
- Intramural young investigator award of the “HILF” initiative
- Women support program of the Hannover Medical school
- Novartis and DebioPharm supported the study by providing reagents
- Helmholtz Association. Grant Numbers: SO-024, HA-202
Additional Supporting Information may be found in the online version of this article.
|HEP_23281_sm_SupFig1.tif||1971K||Supporting Fig. 1: Mutation of NS2-derived P164 to glycine or alanine heavily impairs HCV replication. JFH1-based NS2-5B replicons carrying either a P164G or a P164A mutation within NS2 were constructed and transfected into Huh-7.5 cells. Replication of these constructs as well as given controls in the presence or absence of CsA was determined 48 h later using luciferase assays.|
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