Additional Supporting Information may be found in the online version of this article.

HEP_23281_sm_SupFig1.tif1971KSupporting Fig. 1: Mutation of NS2-derived P164 to glycine or alanine heavily impairs HCV replication. JFH1-based NS2-5B replicons carrying either a P164G or a P164A mutation within NS2 were constructed and transfected into Huh-7.5 cells. Replication of these constructs as well as given controls in the presence or absence of CsA was determined 48 h later using luciferase assays.

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