These authors contributed equally to this work.
Expression and functional significance of Twist1 in hepatocellular carcinoma: Its role in vasculogenic mimicry†
Article first published online: 9 SEP 2009
Copyright © 2009 American Association for the Study of Liver Diseases
Volume 51, Issue 2, pages 545–556, February 2010
How to Cite
Sun, T., Zhao, N., Zhao, X.-l., Gu, Q., Zhang, S.-w., Che, N., Wang, X.-h., Du, J., Liu, Y.-x. and Sun, B.-c. (2010), Expression and functional significance of Twist1 in hepatocellular carcinoma: Its role in vasculogenic mimicry. Hepatology, 51: 545–556. doi: 10.1002/hep.23311
Potential conflict of interest: Nothing to report.
- Issue published online: 25 JAN 2010
- Article first published online: 9 SEP 2009
- Accepted manuscript online: 9 SEP 2009 12:00AM EST
- Manuscript Accepted: 2 SEP 2009
- Manuscript Received: 6 JUL 2009
- Key project of the National Natural Science Foundation of China. Grant Number: 30830049
- National Natural Science Foundation of China. Grant Number: 30770828
- Tianjin Natural Science Foundation. Grant Numbers: 08JCZDJC23500, 09JCYBJC12100, 09ZCZDSF04400
Additional Supporting Information may be found in the online version of this article.
|HEP_23311_sm_suppfig1.tif||585K||Figure S1. Genomic DNA sequence of the proximal 5′-region of the human VE-cadherin gene. The transcription initiation site is designated as +1. The positions of the Ets binding sites (EBSs) are boxed. The 2 functional EBSs present in the murine sequence, and conserved in the human, 30 are indicated by a double-lined box. Nucleotide sequences corresponding to the oligonucleotides used in the ChIP assay are indicated by arrows. The shaded nucleotides at the 5′ and 3′ ends of the sequence denote the position of oligonucleotides used for PCR amplification of the promoter for subsequent cloning into the pGL4 luciferase reporter plasmid. [Graeme M. et al. Blood. 2008, 111:3498-3506]|
|HEP_23311_sm_suppfig2.tif||1324K||Figure S2. IHC negative controls.|
|HEP_23311_sm_suppfig3.tif||450K||Figure s3. Kaplan-Meier survival analysis in HCCs. A. VM and non-VM groups. B. Twist1 positive and negative groups. C. wist1 nuclear positive and negative groups. D. wist2 positive and negative groups. E. VE-cadherin positive and negative groups. F. E-caderhin positive and negative groups. G. MMP2 positive and negative groups. H. MMP9 positive and negative groups|
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