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HEP_23311_sm_supptext.doc54KSupplementary Data
HEP_23311_sm_suppfig1.tif585KFigure S1. Genomic DNA sequence of the proximal 5′-region of the human VE-cadherin gene. The transcription initiation site is designated as +1. The positions of the Ets binding sites (EBSs) are boxed. The 2 functional EBSs present in the murine sequence, and conserved in the human, 30 are indicated by a double-lined box. Nucleotide sequences corresponding to the oligonucleotides used in the ChIP assay are indicated by arrows. The shaded nucleotides at the 5′ and 3′ ends of the sequence denote the position of oligonucleotides used for PCR amplification of the promoter for subsequent cloning into the pGL4 luciferase reporter plasmid. [Graeme M. et al. Blood. 2008, 111:3498-3506]
HEP_23311_sm_suppfig2.tif1324KFigure S2. IHC negative controls.
HEP_23311_sm_suppfig3.tif450KFigure s3. Kaplan-Meier survival analysis in HCCs. A. VM and non-VM groups. B. Twist1 positive and negative groups. C. wist1 nuclear positive and negative groups. D. wist2 positive and negative groups. E. VE-cadherin positive and negative groups. F. E-caderhin positive and negative groups. G. MMP2 positive and negative groups. H. MMP9 positive and negative groups

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