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Additional Supporting Information may be found in the online version of this article.

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HEP_23466_sm_Suppfig1.tif1257KSupplementary Figure 1. One-way sensitivity analysis for age of patients at the moments of initial presentation. The patients were treated with hepatic resection (HR) (Group I), primary percutaneous radiofrequency ablation (RFA) followed by HR for cases of initial local treatment failure (Group II), or percutaneous RFA monotherapy (Group III). Note that in all ages, hepatic resection was superior to other treatment options with regards to overall survival.
HEP_23466_sm_Suppfig2A.tif938KSupplementary Figure 2. Tornado diagrams for hepatic resection (HR) (Group I) (A), primary percutaneous radiofrequency ablation (RFA) followed by HR for cases of initial local treatment failure (Group II) (B), and percutaneous RFA monotherapy (Group III) (C).
HEP_23466_sm_Suppfig2B.tif727KSupplementary Figure 2. Tornado diagrams for hepatic resection (HR) (Group I) (A), primary percutaneous radiofrequency ablation (RFA) followed by HR for cases of initial local treatment failure (Group II) (B), and percutaneous RFA monotherapy (Group III) (C).
HEP_23466_sm_Suppfig2C.tif938KSupplementary Figure 2. Tornado diagrams for hepatic resection (HR) (Group I) (A), primary percutaneous radiofrequency ablation (RFA) followed by HR for cases of initial local treatment failure (Group II) (B), and percutaneous RFA monotherapy (Group III) (C).
HEP_23466_sm_Suppfig3A.tif255KSupplementary Figure 3. The incremental probability distribution of the overall survival depicted for each group of compensated cirrhotic patients, as simulated by a second-order Monte Carlo simulation. The patients were treated by hepatic resection (HR) (Group I), by percutaneous radiofrequency ablation (RFA) followed by HR for cases of initial tumor control failure (Group II), or by percutaneous RFA monotherapy (Group III). (A) The incremental probability distribution of overall survival depicted for Group I compared to Group II (P = 0.309). (B) The incremental probability distribution of overall survival depicted for Group I compared to Group III (P = 0.003). (C) The incremental probability distribution of overall survival depicted for Group II compared to Group III (P = 0.000).
HEP_23466_sm_Suppfig3B.tif292KSupplementary Figure 3. The incremental probability distribution of the overall survival depicted for each group of compensated cirrhotic patients, as simulated by a second-order Monte Carlo simulation. The patients were treated by hepatic resection (HR) (Group I), by percutaneous radiofrequency ablation (RFA) followed by HR for cases of initial tumor control failure (Group II), or by percutaneous RFA monotherapy (Group III). (A) The incremental probability distribution of overall survival depicted for Group I compared to Group II (P = 0.309). (B) The incremental probability distribution of overall survival depicted for Group I compared to Group III (P = 0.003). (C) The incremental probability distribution of overall survival depicted for Group II compared to Group III (P = 0.000).
HEP_23466_sm_Suppfig3C.tif335KSupplementary Figure 3. The incremental probability distribution of the overall survival depicted for each group of compensated cirrhotic patients, as simulated by a second-order Monte Carlo simulation. The patients were treated by hepatic resection (HR) (Group I), by percutaneous radiofrequency ablation (RFA) followed by HR for cases of initial tumor control failure (Group II), or by percutaneous RFA monotherapy (Group III). (A) The incremental probability distribution of overall survival depicted for Group I compared to Group II (P = 0.309). (B) The incremental probability distribution of overall survival depicted for Group I compared to Group III (P = 0.003). (C) The incremental probability distribution of overall survival depicted for Group II compared to Group III (P = 0.000).
HEP_23466_sm_Supptext.doc34KSupporting Information

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