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Expression of pituitary tumor–transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: Evidence for an HBV X protein–mediated inhibition of PTTG1 ubiquitination and degradation†

  1. Francisca Molina-Jiménez1,2,
  2. Ignacio Benedicto1,2,
  3. Miki Murata3,
  4. Samuel Martín-Vílchez2,4,
  5. Toshihito Seki3,
  6. José Antonio Pintor-Toro5,
  7. María Tortolero6,
  8. Ricardo Moreno-Otero2,4,
  9. Kazuichi Okazaki3,
  10. Kazuhiko Koike7,
  11. José Luchi Barbero8,
  12. Koichi Matsuzaki3,
  13. Pedro L. Majano1,2,‡,
  14. Manuel López-Cabrera1,2,9,‡,§,*

Article first published online: 30 NOV 2009

DOI: 10.1002/hep.23468

Issue

Hepatology

Hepatology

Volume 51, Issue 3, pages 777–787, March 2010

Additional Information

How to Cite

Molina-Jiménez, F., Benedicto, I., Murata, M., Martín-Vílchez, S., Seki, T., Antonio Pintor-Toro, J., Tortolero, M., Moreno-Otero, R., Okazaki, K., Koike, K., Barbero, J. L., Matsuzaki, K., Majano, P. L. and López-Cabrera, M. (2010), Expression of pituitary tumor–transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: Evidence for an HBV X protein–mediated inhibition of PTTG1 ubiquitination and degradation. Hepatology, 51: 777–787. doi: 10.1002/hep.23468

Author Information

  1. 1

    Unidad de Biología Molecular, Hospital Universitario de la Princesa, Madrid, Spain

  2. 2

    Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

  3. 3

    Depdatamaticsf Gastroenterology and Hepatogips Kansai Medical University, Osaka, Japan

  4. 4

    Unidad de Hepatología, Hospital Universitario de la Princesa, Madrid, Spain

  5. 5

    Centro Andaluz de Biología Molecular y Medicina Regenerativa, Sevilla, Spain

  6. 6

    Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain

  7. 7

    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

  8. 8

    Departamento de Biología Celular y del Desarrollo, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

  9. 9

    Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain

  1. ‡

    These authors contributed equally to this work.

  2. §

    fax: (34)-91-3093911

*Unidad de Biología Molecular, Hospital Universitario de La Princesa, C/Diego de León 62, 28006 Madrid, Spain

  1. †

    Potential conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 2 MAR 2010
  2. Article first published online: 30 NOV 2009
  3. Accepted manuscript online: 30 NOV 2009 12:00AM EST
  4. Manuscript Accepted: 28 OCT 2009
  5. Manuscript Received: 12 MAR 2009

Funded by

  • CIBERehd (funded by ISCIII)
  • Ministerio de Educación y Ciencia. Grant Number: SAF2007-61201
  • Ministerio de Educación y Ciencia. Grant Numbers: CP03/0020 from ISCIII, SAF2007-60677
  • ISCIII
  • Fundación para la Investigación Biomédica del Hospital Universitario de la Princesa
  • CIBERehd

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