These authors contributed equally to this study.
Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice†
Version of Record online: 30 NOV 2009
Copyright © 2010 American Association for the Study of Liver Diseases
Volume 51, Issue 4, pages 1226–1236, April 2010
How to Cite
Weber, A., Boger, R., Vick, B., Urbanik, T., Haybaeck, J., Zoller, S., Teufel, A., Krammer, P. H., Opferman, J. T., Galle, P. R., Schuchmann, M., Heikenwalder, M. and Schulze-Bergkamen, H. (2010), Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice. Hepatology, 51: 1226–1236. doi: 10.1002/hep.23479
Potential conflict of interest: Nothing to report.
- Issue online: 26 MAR 2010
- Version of Record online: 30 NOV 2009
- Accepted manuscript online: 30 NOV 2009 12:00AM EST
- Manuscript Accepted: 29 OCT 2009
- Manuscript Received: 15 SEP 2009
- Deutsche Forschungsgemeinschaft. Grant Number: DFG SCHU 1443/3-1
- Oncosuisse foundation. Grant Number: OCS 02113-08-2007
- Research foundation at the Medical Faculty Zurich
- Prof. Dr. Max-Cloëtta foundation
Additional Supporting Information may be found in the online version of this article.
|HEP_23479_sm_SupportingFigure1.tif||2500K||Supporting Figure 1 (A) Whole-liver extracts derived from independent 12 month-old wild-type and Mcl-1Δhep mice were analyzed by immunoblot analysis for the expression of Bcl-xL and Tubulin (loading control). kDa: kilo Dalton. (B) Upper panel: mRNA expression analysis of whole liver homogenates derived from wild-type, Mcl-1flox/wt, and Mcl-1Δhep mice for p53 by qRT-PCR. Boxes represent the average expression level. Standard deviation is indicated by error bars. All values are normalized to GAPDH mRNA expression. Lower panel: Representative tumor section showing no p53 expression. Tumor borders are marked by asterisks. (C) Livers of Mcl-1Δhep mice with tumors were analyzed histologically for the expression of VEGF. Tumor borders are marked by asterisks. Scale bar: 100 μm.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.