1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8 "Hepatology")
Potential conflict of interest: Nothing to report.
1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
Hepatology Elsewhere
You have full text access to this OnlineOpen article
Biting the iron bullet: Endoplasmic reticulum stress adds the pain of hepcidin to chronic liver disease†
Article first published online: 26 JAN 2010
DOI: 10.1002/hep.23507
Copyright © 2010 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Messner, D. J., Kowdley, K. V. (2010), Biting the iron bullet: Endoplasmic reticulum stress adds the pain of hepcidin to chronic liver disease. Hepatology, 51: 705–707. doi: 10.1002/hep.23507
- †
Publication History
- Issue published online: 26 JAN 2010
- Article first published online: 26 JAN 2010
References
- 1, , , , , , et al. ER stress controls iron metabolism through induction of hepcidin. Science 2009; 325: 877–880.
- 2, . The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol 2007; 18: 716–731.
- 3, , , , , . Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 2003; 23: 7198–7209.
- 4, , , , , , et al. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J Hepatol 2003; 38: 605–614.
- 5, , . Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J Virol 2002; 76: 7453–7459.
- 6, , , , , , et al. Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Virus Res 2007; 124: 44–49.
- 7, . Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. J Gastroenterol Hepatol 2006; 21(Suppl. 3): S7–S9.
- 8, , . Hereditary hemochromatosis should be considered a conformational disorder. Med Hypotheses 2008; 70: 783–784.
- 9, , , , , , et al. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008; 134: 568–576.
- 10, . Endoplasmic reticulum stress and the unfolded protein response. Clin Liver Dis 2009; 13: 581–590.
- 11, , , , , , et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 2006; 124: 587–599.
- 12, . Regulation of hepcidin and iron-overload disease. Annu Rev Pathol 2009; 4: 489–515.
- 13, , , , , , et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004; 306: 2090–2093.
- 14, , , , , , et al. ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity. PLoS One 2009; 4: e6618.
- 15, , , , , , et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 2008; 112: 1503–1509.
- 16, , , , , , et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet 2009; 41: 482–487.
- 17, . Iron homeostasis: recently identified proteins provide insight into novel control mechanisms. J Biol Chem 2009; 284: 711–715.
- 18, , , , , , et al. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 2002; 277: 41163–41170.
- 19, , , , , , et al. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology 2007; 132: 294–300.
- 20, , , , , . STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 2007; 109: 353–358.
- 21, . HFE-associated hereditary hemochromatosis. Genet Med 2009; 11: 307–313.
- 22, , , , , , et al. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 2007; 13: 97–104.
- 23. Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease? World J Gastroenterol 2009; 15: 1186–1193.
- 24, , , , , , et al. Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. Hepatol Res 2009; 39: 366–373.
- 25, , , , , , et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 2006; 131: 788–796.
- 26, , , , , . Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. J Hepatol 2009; 50: 351–357.