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References

  • 1
    Iwakiri Y, Groszmann RJ. The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. HEPATOLOGY 2006; 43: S121-S131.
  • 2
    Noir B, Groszmann R, DeWalz A. Studies on bilirubin sulphate. Biochim Biophys Acta 1966; 117: 297-394.
  • 3
    Iwakiri Y, Groszmann RJ. Vascular endothelial dysfunction in cirrhosis. J Hepatol 2007; 46: 927-934.
  • 4
    Cohn J. Renal hemodynamic alterations in liver disease. Perspect Neph-Hypertens 1976; 3: 234-255.
  • 5
    Cohn J, Khatri I, Groszmann R, Kotelanski B. Hepatic blood flow in alcoholic liver disease measured by an indicator dilution technique. Am J Med 1972; 53: 704-714.
  • 6
    Groszmann R, Kotelanski B, Cohn J. Hepatic lobar distribution of splenic and mesenteric flow in man. Gastroenterology 1971; 60: 1047-1052.
  • 7
    Groszmann R, Kotelanski B, Cohn J. Quantitation of portasystemic shunting from the splenic and mesenteric beds in alcoholic liver disease. Am J Med 1972; 53: 715-722.
  • 8
    Kotelanski B, Groszmann R, Cohn J. Circulation times in the splanchnic and hepatic beds in alcoholic liver disease. Gastroenterology 1972; 63: 102-111.
  • 9
    Dubin M, Groszmann R, Kravetz D, Costa J, Cantor D. Effect of silimarin on hepatotoxicity induced by carbon tetrachloride in rats. Medicina 1976; 36: 437-442.
  • 10
    Groszmann R, Dubin M, Royer M. A study of the indirect methods to measure hepatic blood flow in the isolated perfused dog liver. Digestion 1975; 13: 220-231.
  • 11
    Groszmann R, Chojkier M, Del Soldato G. Integrated procedure for the diagnosis of hepatobiliary disease of unknown origin. Acta Gast Lat 1974; 6: 137-146.
  • 12
    Groszmann R, Kravetz D, Parysow O. Intrahepatic arteriovenous shunting in cirrhosis of the liver. Gastroenterology 1977; 73: 201-204.
  • 13
    Bissell M. Of Mentors, Mentoring, and Extracellular Matrix. HEPATOLOGY 2009; 50: 1330-1338.
  • 14
    Groszmann R, Glickman M, Blei A, Storer E, Conn H. Wedged and free hepatic venous pressure measured with a balloon catheter. Gastoenterology 1979; 76: 253-258.
  • 15
    Groszmann R, Blei A, Storer E, Conn OH. Intestinal O2 consumption during mechanical and pharmacological reduction in portal pressure. Am J Physiol Gastrointest Liver Physiol 1980; 238: G502-G508.
  • 16
    Chojkier M, Groszmann R. Measurement of portal-systemic shunting in the rat by using γ-labeled microspheres. Am J Physiol Gastrointest Liver Physiol 1981; 240: G371-G375.
  • 17
    Kravetz D, Sikuler E, Groszmann R. Splanchnic and systemic hemodynamics in portal hypertensive rats during hemorrhage and blood volume restitution. Gastroenterology 1986; 90: 1232-1240.
  • 18
    Groszmann R, Vorobioff J, Gao H. Measurement of portal pressure—when, how and why to do it? In: Holland K, LaBrecque DGE, eds. Portal Hypertension Clinics in Liver Disease. Volume 10. Philadelphia, PA: Elsevier; 2006: 499-512.
  • 19
    Reuben A. The way to a man's heart is through his liver. HEPATOLOGY 2003; 37: 1500-1502.
  • 20
    Vorobioff J, Bredfeldt E, Riley E, Groszmann R. Increased splanchnic blood flow in portal hypertensive rats with cirrhosis and chronic portal vein ligation. Gastroenterology 1981; 80: 1353.
  • 21
    Vorobioff J, Bredfeldt J, Groszmann R. Hyperdynamic splanchnic circulation in a portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am J Physiol Gastrointest Liver Physiol 1983; 244: G52-G57.
  • 22
    Colombato L, Albillos A, Groszmann R. Temporal relationship of peripheral vasodilatation, plasma volume expansion and the hyperdynamic circulatory state in portal-hypertensive rats. HEPATOLOGY 1992; 15: 323-328.
  • 23
    Lee F, Albillos A, Colombato L, Groszmann R. The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats. HEPATOLOGY 1992; 16: 1043-1048.
  • 24
    Wiest R, Shah V, Sessa W, Groszmann R. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. Am J Physiol Gastrointest Liver Physiol 1999; 276: G1043-G1051.
  • 25
    Shah V, Wiest R, Garcia-Cardena G, Cadelina G, Groszmann R, Sessa W. Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. American Journal of Physiology (Gastrointestinal and Liver Physiology) 1999; 277: G463-G468.
  • 26
    Iwakiri Y, Tsai M-H, McCabe T, Gratton J-P, Fulton D, Groszmann R, et al. Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension. Am J Physiol Heart Circ Physiol 2002; 282: H2084-H2090.
  • 27
    Gupta T, Toruner M, Chung M, Groszmann R. Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats. HEPATOLOGY 1998; 28: 926-931.
  • 28
    Wiest R, Groszmann R. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. HEPATOLOGY 2002; 35: 478-491.
  • 29
    Sarin S, Groszmann R, Mosca P, Rojkind M, Stadecker M, Bhatnagar R, et al. Propranolol ameliorates the development of portal-systemic shunting in a chronic murine schistosomiasis model of portal hypertension. J Clin Invest 1991; 87: 1032-1036.
  • 30
    Groszmann R, Garcia-Tsao G, Bosch J, Grace N, Burroughs A, Planas R, et al. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 2005; 353: 2254-2261.
  • 31
    Ripoll C, Groszmann R, Garcia-Tsao G, Bosch J, Grace N, Burroughs A, et al. Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis. Gastroenterology 2007; 133: 481-488.
  • 32
    Ripoll C, Groszmann R, Garcia-Tsao G, Bosch J, Grace N, Burroughs A, et al. Hepatic venous pressure gradient predicts development of hepatocellular carcinoma independent of severity of cirrhosis. J Hepatol 2009; 50: 923-928.