• 1
    Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000; 160: 526-534.
  • 2
    Shin DJ, Osborne TF. Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2). J Biol Chem 2003; 278: 34114-34118.
  • 3
    McDermott MT, Ridgway EC. Subclinical hypothyroidism is mild thyroid failure and should be treated. J Clin Endocrinol Metab 2001; 86: 4585-4590.
  • 4
    Teixeira P de F, Reuters VS, Ferreira MM, Almeida CP, Reis FA, Buescu A, et al. Lipid profile in different degrees of hypothyroidism and effects of levothyroxine replacement in mild thyroid failure. Transl Res 2008; 151: 224-231.
  • 5
    Kanaya AM, Harris F, Volpato S, Perez-Stable EJ, Harris T, Bauer DC. Association between thyroid dysfunction and total cholesterol level in an older biracial population: the health, aging and body composition study. Arch Intern Med 2002; 162: 773-779.
  • 6
    Turhan S, Sezer S, Erden G, Guctekin A, Ucar F, Ginis Z, et al. Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism. Ann Saudi Med 2008; 28: 96-101.
  • 7
    Iqbal A, Jorde R, Figenschau Y. Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromso Study. J Intern Med 2006; 260: 53-61.
  • 8
    Davies T, Marians R, Latif R. The TSH receptor reveals itself. J Clin Invest 2002; 110: 161-164.
  • 9
    Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, et al. TSH is a negative regulator of skeletal remodeling. Cell 2003; 115: 151-162.
  • 10
    Zhang W, Tian LM, Han Y, Ma HY, Wang LC, Guo J, et al. Presence of thyrotropin receptor in hepatocytes: not a case of illegitimate transcription. J Cell Mol Med 2009; 13: 4636-4642.
  • 11
    Ness GC, Chambers CM. Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity. Proc Soc Exp Biol Med 2000; 224: 8-19.
  • 12
    Szkudlinski MW, Thotakura NR, Tropea JE, Grossmann M, Weintraub BD. Asparagine-linked oligosaccharide structures determine clearance and organ distribution of pituitary and recombinant thyrotropin. Endocrinology 1995; 136: 3325-3330.
  • 13
    Denereaz N, Lemarchand-Beraud T. Severe but not mild alterations of thyroid function modulate the density of thyroid-stimulating hormone receptors in the rat thyroid gland. Endocrinology 1995; 136: 1694-1700.
  • 14
    Sun Y, Zhang L, Gu HF, Han W, Ren M, Wang F, et al. Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate. Endocrinology 2008; 149: 662-671.
  • 15
    Honda A, Salen G, Matsuzaki Y, Batta AK, Xu G, Leitersdorf E, et al. Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX. J Lipid Res 2001; 42: 291-300.
  • 16
    Honda A, Mizokami Y, Matsuzaki Y, Ikegami T, Doy M, Miyazaki H. Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. J Lipid Res 2007; 48: 1212-1220.
  • 17
    Gauthier BR, Wiederkehr A, Baquie M, Dai C, Powers AC, Kerr-Conte J, et al. PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression. Cell Metab 2009; 10: 110-118.
  • 18
    Heyworth CM, Wallace AV, Houslay MD. Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes. Biochem J 1983; 214: 99-110.
  • 19
    Chen CR, McLachlan SM, Rapoport B. Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity. Endocrinology 2007; 148: 2375-2382.
  • 20
    Chen CR, McLachlan SM, Rapoport B. Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties. Endocrinology 2008; 149: 3427-3434.
  • 21
    Pertusa M, Morenilla-Palao C, Carteron C, Viana F, Cabedo H. Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. J Biol Chem 2007; 282: 28768-28778.
  • 22
    Ngo TT, Bennett MK, Bourgeois AL, Toth JI, Osborne TF. A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of the promoter for 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Biol Chem 2002; 277: 33901-33905.
  • 23
    Kimura T, Van Keymeulen A, Golstein J, Fusco A, Dumont JE, Roger PP. Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models. Endocr Rev 2001; 22: 631-656.
  • 24
    Bell A, Gagnon A, Dods P, Papineau D, Tiberi M, Sorisky A. TSH signaling and cell survival in 3T3-L1 preadipocytes. Am J Physiol Cell Physiol 2002; 283: C1056-C1064.
  • 25
    Agretti P, De Marco G, De Servi M, Marcocci C, Vitti P, Pinchera A, et al. Evidence for protein and mRNA TSHr expression in fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) after adipocytic differentiation. Eur J Endocrinol 2005; 152: 777-784.
  • 26
    Klemm DJ, Roesler WJ, Boras T, Colton LA, Felder K, Reusch JE. Insulin stimulates cAMP-response element binding protein activity in HepG2 and 3T3-L1 cell lines. J Biol Chem 1998; 273: 917-923.
  • 27
    Ness GC, Gertz KR. Increased sensitivity to dietary cholesterol in diabetic and hypothyroid rats associated with low levels of hepatic HMG-CoA reductase expression. Exp Biol Med (Maywood) 2004; 229: 407-411.
  • 28
    Ichi I, Hori H, Takashima Y, Adachi N, Kataoka R, Okihara K, et al. The beneficial effect of propolis on fat accumulation and lipid metabolism in rats fed a high-fat diet. J Food Sci 2009; 74: H127-H131.