Article first published online: 19 AUG 2010
Copyright © 2010 American Association for the Study of Liver Diseases
Volume 52, Issue 4, pages 1455–1464, October 2010
How to Cite
Brufau, G., Stellaard, F., Prado, K., Bloks, V. W., Jonkers, E., Boverhof, R., Kuipers, F. and Murphy, E. J. (2010), Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism. Hepatology, 52: 1455–1464. doi: 10.1002/hep.23831
Potential conflict of interest: Kinemed, Inc., represented in this study by Elizabeth Murphy, is the recipient of a research support from Daiichi Sankyo Inc., in the form of an investigator initiated trial grant to fund this trial. University of Groningen, represented by Folkert Kuipers, received a research grant supported by Daiichi Sankyo to study the effects of colesevelam on bile acid metabolism in mice. Both Dr. Murphy and Kuipers have acted as consultants to Daiichi Sankyo within the past year. Dr. Murphy is no longer a consultant.
The goal of this mechanistic study is to evaluate the interaction between differences in glucose control and differences in bile acid kinetics. Data reported here are focused on the underlying physiologic effects of the drug on bile acid kinetics and not on clinical outcomes or treatment for a medical condition.
Trial is registered at Clinicaltrials.gov. “Effects of colesevelam on bile acid kinetics” www.clinicaltrials.gov/ct2/show/NCT00476710?term=colesevelam+bile+acids&rank=1
- Issue published online: 28 SEP 2010
- Article first published online: 19 AUG 2010
- Manuscript Accepted: 25 JUN 2010
- Manuscript Received: 8 MAR 2010
Additional Supporting Information may be found in the online version of this article.
|HEP_23831_sm_suppinfofigureandtable.doc||90K||Supporting Figure 1. Study protocol outline. Supporting Table 1. Bile acid kinetic parameters in control subjects and in type 2 diabetic subjects at baseline and after 2 and 8 weeks of treatment with colesevelam|
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