Steatohepatitis/Metabolic Liver Disease
Article first published online: 21 OCT 2010
Copyright © 2010 American Association for the Study of Liver Diseases
Volume 52, Issue 6, pages 1980–1991, December 2010
How to Cite
Martínez-Clemente, M., Ferré, N., Titos, E., Horrillo, R., González-Périz, A., Morán-Salvador, E., López-Vicario, C., Miquel, R., Arroyo, V., D. Funk, C. and Clària, J. (2010), Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Hepatology, 52: 1980–1991. doi: 10.1002/hep.23928
Supported by a grant from the Ministry of Science and Innovation (MICINN) (SAF 09/08767). The Biomedical Research Networking Center on Liver and Digestive Diseases (CIBERehd) is funded by Carlos III Health Institute. Our laboratory is a consolidated research group recognized by the Generalitat de Catalunya (2009SGR1484). M. M.-C. was supported by MICINN (contract number BES-2007-16147). E. T. and A. G.-P. had contracts with CIBERehd. N. F. (Juan de la Cierva Program) and E. M.-S. were supported by MICINN. C. L.-V. was supported by August Pi i Sunyer Biomedical Research Institute. C. D. F. holds a Tier I Canada Research Chair in Molecular, Cellular, and Physiological Medicine and is a Carrer Investigator of the Heart and Stroke Foundation of Ontario.
Potential conflict of interest: Nothing to report.
- Issue published online: 23 NOV 2010
- Article first published online: 21 OCT 2010
- Accepted manuscript online: 20 AUG 2010 12:00AM EST
- Manuscript Accepted: 10 AUG 2010
- Manuscript Received: 21 MAY 2010
Additional Supporting Information may be found in the online version of this article.
|23928SupplementaryFigure1.tiff||149K||Supplementary Figure 1. Effects of Alox15 gene disruption on adipose tissue in apolipoprotein E-deficient (ApoE−/−) mice. The expression of MCP-1, TNFα, IL-6, IRS-1, GLUT-4 and PPARγ in adipose tissue samples from WT, ApoE−/− and ApoE−/−;12/15-LO−/− mice was assessed by real-time PCR. Results are expressed as mean ± SEM. *, P<0.05 versus WT mice; a, P<0.05 versus ApoE−/− mice.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.