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HEP_23984_sm_suppinfofigures.doc421KSupplemental Fig. 1. Hepatic mRNA expression of bile acid-CoA ligase (BAL) and Bile acid CoA:amino acid:N-acyltransferase (BAT) in male 2-month old wild-type and Oatp1b2-null mice. Bars represents the relative percentage mRNA expression ± SE of 5-6 mice. Supplemental Fig. 2. Serum concentration of unconjugated bile acids in male 1-year old Wild-type, Oatp1b2+/−, and Oatp1b2-null mice. Bars Represents means±SEM of 3 to 6 mice. The unconjugated bile acid concentration was inversely related to the amount of Oatp1b2 gene. Supplemental Fig 3. Relative BA concentrations in the contents of the small intestine of wild-type and Oatp1b2-null mice. Bars represents means ± SEM of 5 to 6 mice. Supplemental Fig 4 Serum and hepatic concentration of cholesterol in male 2-months old wild-type and Oatp1b2-null mice. Bars represent means ± SE of 6 mice. Asterisks indicate a statistically significant difference (p < 0.05) from the respective value of the wild-type mice.Supplemental Fig. 5. mRNA expression of BA sensor genes in the ilea of male 1-year old Wild-type and Oatp1b2-null mice. Bars represents the relative percentage mRNA expression ± SE of 4-5 mice. Asterisk indicate a statistically significant difference (p<0.05) from from the respective value of the wild-type mice.
23984.DOC42KSupporting Table 1

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