These authors contributed equally to this work.
Article first published online: 14 OCT 2010
Copyright © 2010 American Association for the Study of Liver Diseases
Volume 53, Issue 1, pages 272–281, January 2011
How to Cite
Csanaky, I. L., Lu, H., Zhang, Y., Ogura, K., Choudhuri, S. and Klaassen, C. D. (2011), Organic anion–transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology, 53: 272–281. doi: 10.1002/hep.23984
This work was presented in part as a lecture at the Liver Meeting (November 1, 2010, Boston MA).
Potential conflict of interest: Nothing to report.
- Issue published online: 12 JAN 2011
- Article first published online: 14 OCT 2010
- Accepted manuscript online: 14 SEP 2010 08:04AM EST
- Manuscript Accepted: 3 SEP 2010
- Manuscript Received: 1 JUN 2010
- National Institutes of Health Grants. Grant Numbers: ES09649, ES09716, ES013714, RR021940
Additional Supporting Information may be found in the online version of this article.
|HEP_23984_sm_suppinfofigures.doc||421K||Supplemental Fig. 1. Hepatic mRNA expression of bile acid-CoA ligase (BAL) and Bile acid CoA:amino acid:N-acyltransferase (BAT) in male 2-month old wild-type and Oatp1b2-null mice. Bars represents the relative percentage mRNA expression ± SE of 5-6 mice. Supplemental Fig. 2. Serum concentration of unconjugated bile acids in male 1-year old Wild-type, Oatp1b2+/−, and Oatp1b2-null mice. Bars Represents means±SEM of 3 to 6 mice. The unconjugated bile acid concentration was inversely related to the amount of Oatp1b2 gene. Supplemental Fig 3. Relative BA concentrations in the contents of the small intestine of wild-type and Oatp1b2-null mice. Bars represents means ± SEM of 5 to 6 mice. Supplemental Fig 4 Serum and hepatic concentration of cholesterol in male 2-months old wild-type and Oatp1b2-null mice. Bars represent means ± SE of 6 mice. Asterisks indicate a statistically significant difference (p < 0.05) from the respective value of the wild-type mice.Supplemental Fig. 5. mRNA expression of BA sensor genes in the ilea of male 1-year old Wild-type and Oatp1b2-null mice. Bars represents the relative percentage mRNA expression ± SE of 4-5 mice. Asterisk indicate a statistically significant difference (p<0.05) from from the respective value of the wild-type mice.|
|23984.DOC||42K||Supporting Table 1|
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