These authors contributed equally to this work.
Autoimmune, Cholestatic and Biliary Disease
Importance of hepatic fibrosis in cystic fibrosis and the predictive value of liver biopsy†
Version of Record online: 17 NOV 2010
Copyright © 2010 American Association for the Study of Liver Diseases
Volume 53, Issue 1, pages 193–201, January 2011
How to Cite
Lewindon, P. J., Shepherd, R. W., Walsh, M. J., Greer, R. M., Williamson, R., Pereira, T. N., Frawley, K., Bell, S. C., Smith, J. L. and Ramm, G. A. (2011), Importance of hepatic fibrosis in cystic fibrosis and the predictive value of liver biopsy. Hepatology, 53: 193–201. doi: 10.1002/hep.24014
Potential conflict of interest: Nothing to report.
- Issue online: 12 JAN 2011
- Version of Record online: 17 NOV 2010
- Accepted manuscript online: 30 SEP 2010 09:17AM EST
- Manuscript Accepted: 10 SEP 2010
- Manuscript Received: 8 JUN 2010
- National Health and Medical Research Council of Australia. Grant Numbers: 290220, 496602, 552409
- Royal Children's Hospital Foundation of Brisbane. Grant Number: 913-005
- Bushell Foundation postdoctoral research fellowship from the Gastroenterological Society of Australia
Additional Supporting Information may be found in the online version of this article.
|HEP_24014_sm_suppFig-S1.tif||410K||Supplemental Figure 1: Quantitative analysis of α-SMA immunohistochemistry (marker of activated hepatic stellate cells and myofibroblasts) vs Scheuer (18) fibrosis staging in liver biopsies from 40 patients with suspected CFLD. α-SMA expression was significantly associated with increasing stage of hepatic fibrosis (***p<0.001). Note the non-linear change with increasing fibrosis stage. α-SMA, alpha-smooth muscle actin.|
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