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Effect of sorafenib on murine liver regeneration†
Version of Record online: 4 JAN 2011
Copyright © 2010 American Association for the Study of Liver Diseases
Volume 53, Issue 2, pages 577–586, February 2011
How to Cite
Hora, C., Romanque, P. and Dufour, J.-F. F. (2011), Effect of sorafenib on murine liver regeneration. Hepatology, 53: 577–586. doi: 10.1002/hep.24037
Potential conflict of interest: Dr. Dufour advises and receives grants from Bayer. He also receives grants from Novartis.
- Issue online: 27 JAN 2011
- Version of Record online: 4 JAN 2011
- Accepted manuscript online: 11 OCT 2010 08:53AM EST
- Manuscript Accepted: 28 SEP 2010
- Manuscript Received: 21 MAY 2010
- C.H. is supported by the Stiftung für die Leberkrankheiten. J.F.D. is a recipient of grants from the Swiss National Foundation, Oncosuisse, and the Sassella Foundation
Additional Supporting Information may be found in the online version of this article.
|HEP_24037_sm_suppfigure1.tif||42080K||Liver pERK levels - histology. Immunohistochemical staining for phosphorylated ERK (pERK). Examples of immunohistochemical staining for the 0h (hepatectomy) and 72h time point are shown, illustrating the corresponding time points in figure 4. The left panels show nuclear pERK staining at the time of hepatectomy, the right panels are representative of pERK staining at the 72h time point. The top row illustrates the findings in a vehicle treated animal, the findings in the sorafenib treatment groups are shown in the lower rows.|
|HEP_24037_sm_suppfigure2.tif||361K||HGF hepatic levels. HGF protein content measured by ELISA from whole liver lysate, showing protein levels at baseline (hepatectomy) and at sacrifice. A, animals treated with sorafenib or vehicle until one day before surgery. B, animals treated with sorafenib or vehicle continuously. C, animals treated with sorafenib or vehicle after surgery. Black bars: vehicle treated mice; grey bars: sorafenib treated mice. At the time of hepatectomy there was a slight increase in HGF levels in the animals that stopped sorafenib one day before hepatectomy when compared to controls. This was also observed at 72h after hepatectomy, however, neither increase were significative (A). The animals receiving continuous sorafenib treatment presented decreased HGF levels at 24h when compared to controls, and also when compared to baseline levels (0h) (B). The group receiving continuous treatment and the group starting sorafenib after hepatectomy both showed elevated HGF levels at 120h when compared to controls, although this was not significant (B and C). Values are mean ± SD. * indicates statistical significance (p<0.05) versus vehicle treated control mice.|
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