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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
HEP_24072_sm_SuppinfoFigure1.tif26148KSupporting Figure 1. Linkage disequilibrium (R2) between single nucleotide polymorphisms in APO A5/A4/C3/A1 gene cluster on chromosome 11q23 in the African-Americans (top), European-Americans (middle) and Hispanics (bottom) in the Dallas Heart Study. Gene and SNP positions correspond to NCBI genome build 34 (July 2003). SNPs were genotyped using a custom oligonucleotide genotyping array (Perlegen Sciences). Correlations were calculated from genotype data of 1,730 African Americans, 996 European Americans and 581 Hispanics. Only common variants (minor allele frequency (MAF) of ≥ 5%) are shown in the correlation map for each ethnic group.
HEP_24072_sm_SuppinfoFigure2.tif17704KSupporting Figure 2. Linkage disequilibrium (R2) between 41 single nucleotide polymorphisms in the APO A5/A4/C3/A1 gene cluster on chromosome 11q23 in African-Americans (top), European-Americans (bottom) in the ARIC study. Gene and SNP positions correspond to NCBI genome build 36 (March 2006).
HEP_24072_sm_SuppinfoTables.doc210KSupporting Table 1. Oligonucleotides used for genotyping APOC3 SNPs in the Dallas Heart Study (DHS) population and in Atherosclerosis Risk in Communities (ARIC) study. Supporting Table 2. Clinical characteristics of the Dallas Heart Study participants stratified by APOC3 rs2854117 genotype and ethnicity. Supporting Table 3. Clinical characteristics of the Dallas Heart Study participants stratified by APOC3 rs2854116 genotype and ethnicity. Supporting Table 4. Clinical characteristics of the Dallas Heart Study participants stratified by APOC3 rs2854117 genotype Supporting Table 5. Clinical characteristics of the Dallas Heart Study participants stratified by APOC3 rs2854116 genotype. Supporting Table 6. Clinical characteristics of Atherosclerosis Risk in Communities study (ARIC) participants stratified by APOC3 rs2854117 genotype and ethnicity. Supporting Table 7. Clinical characteristics of Atherosclerosis Risk in Communities study (ARIC) participants stratified by APOC3 rs2854116 genotype and ethnicity. Supporting Table 8. Clinical characteristics of APOC3 wild-type homozygotes (rs2854117 C/C and rs2854116 T/T) compared to carriers of one or more variant alleles (rs2854117 T and rs2854116 C) in Atherosclerosis Risk in Communities study (ARIC) participants, stratified by ethnicity.

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