Potential conflicts of interest: X.F. received an unrestricted grant support from Schering and Roche. M.G. is currently employed by Bitplane but his affiliation was the one stated above during the period of study design, laboratory work, and article preparation.
Article first published online: 3 FEB 2011
Copyright © 2011 American Association for the Study of Liver Diseases
Volume 53, Issue 5, pages 1436–1445, May 2011
How to Cite
Mensa, L., Crespo, G., Gastinger, M. J., Kabat, J., Pérez-del-Pulgar, S., Miquel, R., Emerson, S. U., Purcell, R. H. and Forns, X. (2011), Hepatitis C virus receptors claudin-1 and occludin after liver transplantation and influence on early viral kinetics. Hepatology, 53: 1436–1445. doi: 10.1002/hep.24110
X. Forns received support in part by a grant from Instituto de Salud Carlos III (PI080239), cofunded by the European Regional Development Fund (ERDF), and by the Spanish Association for the Study of Liver Diseases (AEEH, Beca Hernández-Guío). G. Crespo was supported by Hospital Clinic (Ajut a la Recerca Josep Font) and Fundación BBVA. L. Mensa was supported by Instituto de Salud Carlos III (PFIS). This study was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health.
- Issue published online: 22 APR 2011
- Article first published online: 3 FEB 2011
- Accepted manuscript online: 14 DEC 2010 05:44PM EST
- Manuscript Accepted: 29 NOV 2010
- Manuscript Received: 15 JUN 2010
Additional supporting information may be found in the online version of this article.
|HEP_24110_sm_suppinfofig.tif||123K||Supporting Figure 1. Sum of intensities (SI) and mRNA (as determined by real-time PCR) box plots for claudin-1 and occludin over time. In HCV-infected patients (A,D), there was a significant increase in the levels of claudin-1 and occludin 12 months after LT (p= 0.007 and p= 0.03, respectively). In HCV-negative patients, the levels of both proteins remained unchanged over time (B,E). In contrast, mRNA claudin-1 levels remained unchanged (C); occludin mRNA levels increased overtime; however, the difference was not statistically significant (F).|
|HEP_24110_sm_suppinfotable.doc||27K||Supporting Table 1. Quantification of the levels of claudin-1 and occludin over time. The numbers represent the sum of intensities of claudin-1 and occludin at each time point. Values are depicted as median (ranges) in a logarithmic scale. Pre-LT: biopsies obtained at time of graft reperfusion; 3M: 3 months after liver transplantation; 12M: 12 months after liver transplantation.|
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